ArticleScientific reports2024
Analysis of detoxification kinetics and end products of furan aldehydes in Acinetobacter baylyi ADP1.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Real-time NMR monitoring of HMF biotransformation by Ectopseudomonas oleovorans CECT 5344 R1D.Applied microbiology and biotechnology · 2026Article
- Metagenomic insights into microbial diversity, xenobiotic and plastic-degrading enzymes in sediments of river Yamuna at Agra.Frontiers in microbiology · 2026Article
- Conversion and upgrading of syringate by Acinetobacter baylyi ADP1.Microbial cell factories · 2025Article
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Authors and funding
4 authors.
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Abstract
The efficient utilization of lignocellulosic hydrolysates in bioprocesses is impeded by their complex composition and the presence of toxic compounds, such as furan aldehydes, formed during lignocellulose pretreatment. Biological detoxification of these furan aldehydes offers a promising solution to enhance the utilization of lignocellulosic hydrolysates. Acinetobacter baylyi ADP1 is known to metabolize furan aldehydes, yet the complete spectrum of reaction products and dynamics remains unclear. Here, we determined the detoxification metabolites of furfural and 5-hydroxymethylfurfural in A. baylyi ADP1 and studied the kinetics of detoxification. The results indicate that detoxification in A. baylyi ADP1 follows a typical alcohol-aldehyde-acid scheme, with furoic acid and 5-hydroxymethyl-2-furancarboxylic acid as the final products for furfural and 5-hydroxymethylfurfural, respectively. Both end products were found to be less toxic for cells than their unmodified forms. These findings underscore the potential of A. baylyi ADP1 in detoxifying lignocellulosic hydrolysates for bioprocess applications.
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