Evidence map›Paper›PMID 39613759›Full record

ArticleNPJ vaccines2024

Mass cytometry reveals cellular correlates of immune response heterogeneity to SARS-CoV-2 vaccination in the elderly.

Ratnadeep Mukherjee, Linn Margrethe Eggesbø, Asia-Sophia Wolf, Ingrid Fadum Kjønstad, Guri Solum, Anthony Ravussin, Sabin Bhandari, Anna Hayman Robertson, Per Magnus, Lill Trogstad and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ratnadeep MukherjeeDivision of Infection Control, Section for Immunology, Norwegian Institute of Public Health, Oslo, Norway. ratnadeep.mukherjee@fhi.no.ORCID http://orcid.org/0000-0002-4874-4493
Linn Margrethe EggesbøDivision of Infection Control, Section for Immunology, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-5271-7703
Asia-Sophia WolfDivision of Infection Control, Section for Immunology, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0003-1982-9487
Ingrid Fadum KjønstadDivision of Infection Control, Section for Immunology, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0001-5306-3492
Guri SolumDivision of Infection Control, Section for Immunology, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-5269-5727
Anthony RavussinDivision of Infection Control, Section for Immunology, Norwegian Institute of Public Health, Oslo, Norway.
Sabin BhandariDivision of Infection Control, Section for Immunology, Norwegian Institute of Public Health, Oslo, Norway.
Anna Hayman RobertsonDivision of Infection Control, Section for Vaccine Epidemiology and Population Studies, Norwegian Institute of Public Health, Oslo, Norway.
Per MagnusCentre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-6427-4735
Lill TrogstadDivision of Infection Control, Section for Vaccine Epidemiology and Population Studies, Norwegian Institute of Public Health, Oslo, Norway.
Anja Bråthen KristoffersenDivision of Infection Control, Section for Modelling and Bioinformatics, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0003-2313-9622
Unni Cecilie NygaardDivision of Infection Control, Section for Immunology, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-2955-9970
Siri MjaalandDivision of Infection Control, Section for Immunology, Norwegian Institute of Public Health, Oslo, Norway.ORCID http://orcid.org/0000-0002-3870-5861

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heterogeneity in vaccine response, particularly in vulnerable populations like the elderly, represents a significant public health challenge. We conducted an in-depth examination of immune cell profiles before and after SARS-CoV-2 vaccination utilizing mass cytometry in a cohort of healthy Norwegian seniors (65-80 years). We have demonstrated that higher pre-vaccination frequencies of CD27

Identifiers

PMID39613759
PMCPMC11607307

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.