Evidence map›Paper›PMID 39613505›Full record

ArticleNeurobiology of aging2025

Lifespan longitudinal changes in mesocortical thickness and executive function: Role of dopaminergic genetic predisposition.

Giuseppe G Miranda, Chen Gonen, Jessica N Kraft, Karen M Rodrigue, Kristen M Kennedy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Methylglyoxal Affects Dopamine Homeostasis in SH-SY5Y Cells Through the Modulation of miR-190a and miR-214.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Giuseppe G MirandaDepartment of Psychology, School of Behavioral and Brain Sciences, Center for Vital Longevity, The University of Texas at Dallas, 1600 Viceroy Dr, Ste 800, Dallas, TX 75235 USA, United States.
Chen GonenDepartment of Psychology, School of Behavioral and Brain Sciences, Center for Vital Longevity, The University of Texas at Dallas, 1600 Viceroy Dr, Ste 800, Dallas, TX 75235 USA, United States.
Jessica N KraftDepartment of Psychology, School of Behavioral and Brain Sciences, Center for Vital Longevity, The University of Texas at Dallas, 1600 Viceroy Dr, Ste 800, Dallas, TX 75235 USA, United States.
Karen M RodrigueDepartment of Psychology, School of Behavioral and Brain Sciences, Center for Vital Longevity, The University of Texas at Dallas, 1600 Viceroy Dr, Ste 800, Dallas, TX 75235 USA, United States.
Kristen M KennedyDepartment of Psychology, School of Behavioral and Brain Sciences, Center for Vital Longevity, The University of Texas at Dallas, 1600 Viceroy Dr, Ste 800, Dallas, TX 75235 USA, United States. Electronic address: kristen.kennedy1@utdallas.edu.

Funding

Dopaminergic and Neuroplastic Influences on Longitudinal Change in Cognitive and Brain AgingR01AG056535 · NIA · UNIVERSITY OF TEXAS DALLAS · PI Kristen M. Kennedy, Karen M Rodrigue · 2017 to 2026
$4.8M
Role of White Matter Integrity in Age-Related Functional ReorganizationR00AG036818 · NIA · UNIVERSITY OF TEXAS DALLAS · PI KENNEDY, KRISTEN M. · 2012 to 2014
$733k
Vascular Effects on Normal Neural and Cognitive AgingR00AG036848 · NIA · UNIVERSITY OF TEXAS DALLAS · PI RODRIGUE, KAREN M · 2012 to 2014
$733k
Role of White Matter Integrity in Age-Related Functional ReorganizationK99AG036818 · NIA · UNIVERSITY OF TEXAS DALLAS · PI KENNEDY, KRISTEN M. · 2010 to 2011
$179k
Vascular Effects on Normal Neural and Cognitive AgingK99AG036848 · NIA · UNIVERSITY OF TEXAS DALLAS · PI RODRIGUE, KAREN M · 2010 to 2011
$179k
NIA NIH HHS K99 AG036818NIA NIH HHS K99 AG036848NIA NIH HHS R00 AG036818NIA NIH HHS R00 AG036848NIA NIH HHS R01 AG056535
6 · The paper itself

Abstract

Dopamine (DA) signaling is critical for optimal cognitive aging, especially in prefrontal-parietal and fronto-striatal networks. Single nucleotide polymorphisms associated with dopamine regulation, COMTVal158Met and DRD2C957T, stand to exert influence on executive function performance via neural properties. The current study investigated whether longitudinal thinning of mesocortical regions is related to COMT and DRD2 genetic predisposition and associated with decline in executive function over four-years. N=235 healthy adults aged 20-94 years were recruited, with n=124 returning 4-years later. Latent mixed effects modeling revealed dopamine-related thinning in several frontal, parietal, and cingulate regions as well as decline in verbal fluency category switching across 4-years. Mesocortical thinning was also related to switching performance. Greater cortical thinning interacted with DA-genotype risk for lower DA-availability to predict poorer switching performance in parietal and posterior cingulate cortex. These findings lend support to the notion that early-life factors, such as genetic influence on neurotransmitter function, play a role in cognitive and brain aging and their linked association.

Indexed as

DopamineExecutive FunctionPolymorphism, Single NucleotideReceptors, Dopamine D2AdultAgedAged, 80 and overAgingCatechol O-MethyltransferaseCognitive AgingFemaleGenetic Predisposition to DiseaseGenotypeHumansLongevityLongitudinal StudiesCatechol O-MethyltransferaseCOMT protein, humanDopamineDRD2 protein, humanReceptors, Dopamine D2COMT Val158MetCortical thicknessDopamineDRD2 C957TExecutive functionLongitudinal

Identifiers

PMID39613505
PMCPMC12024007

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.