Evidence map›Paper›PMID 39613503›Full record

ArticleEarly human development2025

Preoperative autonomic failure in neonates with critical congenital heart disease.

R B Govindan, Stefano Pezzato, Julius Ngwa, Anita Krishnan, Eleni Panagopoulos, Venkata Chaitanya Chirumamilla, Adre du Plessis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Early human development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

R B GovindanThe Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA; The Developing Brain Institute, Children's National Hospital, Washington, DC, USA; Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA.
Stefano PezzatoNeonatal and Pediatric Intensive Care Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy; Division of Cardiac Surgery, Children's National Hospital, Washington, DC, USA.
Julius NgwaThe Developing Brain Institute, Children's National Hospital, Washington, DC, USA.
Anita KrishnanDepartment of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA; Division of Cardiology, Children's National Hospital, Washington, DC, USA.
Eleni PanagopoulosThe Developing Brain Institute, Children's National Hospital, Washington, DC, USA.
Venkata Chaitanya ChirumamillaThe Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA; The Developing Brain Institute, Children's National Hospital, Washington, DC, USA.
Adre du PlessisThe Zickler Family Prenatal Pediatrics Institute, Children's National Hospital, Washington, DC, USA; The Developing Brain Institute, Children's National Hospital, Washington, DC, USA; Department of Pediatrics, The George Washington University School of Medicine, Washington, DC, USA. Electronic address: adupless@childrensnational.org.

Funding

Impaired Brain Development in a Premature Ex-utero EnvironmentR01HD099393 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI DU PLESSIS, ADRE JACQUES, LIMPEROPOULOS, CATHERINE · 2020 to 2024
$3.4M
Diversity Supplement: Clinical Pediatric Research Training for the Fetal-Neonatal BrainT32HD098066 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI DU PLESSIS, ADRE JACQUES, LIMPEROPOULOS, CATHERINE · 2020 to 2024
$1.7M
NICHD NIH HHS R01 HD099393NICHD NIH HHS T32 HD098066
6 · The paper itself

Abstract

backgroundNeonates with critical congenital heart disease (cCHD) undergo a complicated transition to ex-utero life. However, continuous monitoring of autonomic tone using heart rate variability is currently lacking. MATERIALS AND

methodsWe retrieved continuous electrocardiograms from the time of admission or from 10 days prior to surgery for neonates with dextro-transposition of the great arteries (d-TGA) and hypoplastic left heart syndrome (HLHS). Beat-to-beat intervals (RRi) were calculated and divided into 10-min epochs. Spectral metrics, including low-frequency (LF) and high-frequency (HF) powers, as well as detrended fluctuation analysis metrics (α

resultsThe study included 10 neonates with HLHS and 23 with d-TGA. RRi metrics were available for 110 days. In the unadjusted models, LF power (Estimate: -4.4×10

conclusionsIn neonates with cCHD, there is a progressive decline in autonomic function leading up to surgery. RRi metrics may serve as valuable indicators of deteriorating physiology in these patients.

Indexed as

Hypoplastic Left Heart SyndromeAutonomic Nervous SystemElectrocardiographyFemaleHeart Defects, CongenitalHeart RateHumansInfant, NewbornMaleTransposition of Great VesselsAutonomic dysfunctionCritical congenital heart diseaseHeart rate variablityHypoplastic left heart syndromePreoperative monitoring

Identifiers

PMID39613503
PMCPMC11804807

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.