Evidence map›Paper›PMID 39613443›Full record

ArticleBMJ open2024

Evaluation of BBIBP-CorV Sinopharm COVID-19 vaccine effectiveness in Sri Lanka: a test-negative case control study.

Shamila Thivanshi De Silva, Dileepa Senajith Ediriweera, Wathsala Wimalasena, Manjula Kariyawasam, Gihan Kosinna, Gayan Bogoda, Sumudu Senaratne, Kanchana Rathnayake, Inosha Weerarathna, Ranjan Premaratna and 1 more

Abstract readMulticenter Study
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shamila Thivanshi De SilvaFaculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka shamiladp@kln.ac.lk.ORCID http://orcid.org/0000-0001-7241-0963
Dileepa Senajith EdiriweeraCentre for Health Informatics, Biostatistics and Epidemiology, University of Kelaniya Faculty of Medicine, Ragama, Sri Lanka.
Wathsala WimalasenaState Pharmaceuticals Corporation of Sri Lanka, Colombo, Sri Lanka.
Manjula KariyawasamEpidemiology Unit, Ministry of Health, Sri Lanka, Colombo, Sri Lanka.
Gihan KosinnaState Pharmaceuticals Corporation of Sri Lanka, Colombo, Sri Lanka.
Gayan BogodaState Pharmaceuticals Corporation of Sri Lanka, Colombo, Sri Lanka.
Sumudu SenaratneState Pharmaceuticals Corporation of Sri Lanka, Colombo, Sri Lanka.
Kanchana RathnayakeState Pharmaceuticals Corporation of Sri Lanka, Colombo, Sri Lanka.
Inosha WeerarathnaState Pharmaceuticals Corporation of Sri Lanka, Colombo, Sri Lanka.
Ranjan PremaratnaFaculty of Medicine, University of Kelaniya, Kelaniya, Sri Lanka.
Prasanna GunasenaState Pharmaceuticals Corporation of Sri Lanka, Colombo, Sri Lanka.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThere is limited research on real-world effectiveness of BBIBP-CorV Sinopharm COVID-19 vaccine. This study evaluated real-world effectiveness of Sinopharm vaccine in Sri Lanka by assessing absolute vaccine efficacy. DESIGN AND

settingA retrospective test-negative case-control study was conducted at ten large government hospitals across the country.

participantsConsecutive adults aged ≥18 years attending outpatient departments who tested reverse-transcription-PCR positive for SARS-CoV-2 during the study period were recruited.

main outcome measuresAn interviewer-administered questionnaire was administered, and outcome of COVID-19 infection was assessed in cases.

resultsOf 1829 recruited, 914 (49.9%) were male, and mean age was 45.2 (SD 15.3) years; 1634 (89.3%) were vaccinated with two doses of BBIBP-CorV Sinopharm vaccine, while 195 (10.1%) were vaccine-naïve. Compared with the vaccinated, unvaccinated persons were older but otherwise similar in their demographic and medical profiles. Unvaccinated were more likely to have fever, shortness of breath and vomiting as symptoms and were more likely to seek treatment. Significantly more vaccinated individuals received treatment at home. After admission, the unvaccinated were more likely to receive oxygen. Significantly more unvaccinated persons died of COVID-19 compared with the vaccinated. Sinopharm vaccine was 78.2% (94% CI 69.0% to 85.0%) effective at preventing COVID-19 infection, 88.7% (81.6%-93.2%) effective at preventing severe infection and 85.6% (69.6%-93.6%) effective at preventing death.

conclusionsBBIBP-CorV Sinopharm vaccine is effective at mitigating severity of illness and reducing the likelihood of hospitalisation, severe illness and death, in those who received primary vaccination, compared with the unvaccinated.

Indexed as

COVID-19COVID-19 VaccinesSARS-CoV-2Vaccine EfficacyAdultAgedCase-Control StudiesFemaleHospitalizationHumansMaleMiddle AgedRetrospective StudiesSri LankaVaccines, InactivatedBIBP COVID-19 vaccineCOVID-19 VaccinesVaccines, InactivatedCOVID-19PUBLIC HEALTHVaccination

Identifiers

PMID39613443
PMCPMC11605810

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.