Evidence map›Paper›PMID 39612119›Full record

ArticleJournal of natural medicines2025

Pharmacokinetics of seven major components in Aβ

Junzuo Zheng, Jun Wang, Linlin Chen, Xuelian Jiang, Xuesong Zhang, Wenqi Ai, Yuman Xie, Ping Wang, Zhou Lan, Xiaoping Ding

Abstract read
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In one paragraph

Article in Journal of natural medicines, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Junzuo ZhengSchool of Pharmacy, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic of China.
Jun WangOutpatient Department, Shenyang 14th retired cadres recuperation Clinic of Liaoning Military District, Shenyang, 110031, People's Republic of China.
Linlin ChenSchool of Pharmacy, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic of China.
Xuelian JiangSchool of Pharmacy, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic of China.
Xuesong ZhangSchool of Pharmacy, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic of China.
Wenqi AiSchool of Pharmacy, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic of China.
Yuman XieSchool of Pharmacy, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic of China.
Ping WangEngineering Research Center of TCM Protection Technology and New Product Development for the Elderly Brain Health, Ministry of Education, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic of China.
Zhou LanSchool of Pharmacy, Hubei Shizhen Laboratory, Hubei University of Chinese Medicine, Wuhan, 430065, People's Republic of China. lzlz_84@163.com.ORCID http://orcid.org/0000-0002-6241-5573
Xiaoping DingCenter for Drug Quality Control, Hubei Institute for Drug Control, Wuhan, 430071, People's Republic of China. dxp2888@126.com.

Funding

Distinguished Young Scholars of Hubei University of Chinese Medicine 2022ZZXJ005Natural Science Foundation of Hubei Province 2023AFD108Ten Thousand Talent Plans for Young Top-notch Talents of Yunnan Province 2023
6 · The paper itself

Abstract

Alzheimer's disease (AD) is the main cause of dementia. Aβ-mediated neuroinflammation plays a crucial role in the development of AD. Curculiginis Rhizoma and Epimedii Folium, frequently used in combination for their synergistic effects, have shown promise for cognitive improvement and anti-inflammatory properties in previous studies. This study, for the first time, investigates the pharmacokinetic profile of seven key compounds in the aqueous extract of Curculiginis Rhizoma and Epimedii Folium (CREF) in both normal and Aβ

Indexed as

Amyloid beta-PeptidesDrugs, Chinese HerbalEpimediumPeptide FragmentsPlant ExtractsAdministration, OralAlzheimer DiseaseAnimalsAporphinesBenzoatesChromatography, High Pressure LiquidFlavonoidsGlucosidesMaleRatsRats, Sprague-DawleyAmyloid beta-Peptidesamyloid beta-protein (1-42)Aporphinesbaohuoside IBenzoatescurculigosideDrugs, Chinese Herbalepimedin BFlavonoidsGlucosidesicariinmagnoflorinePeptide FragmentsPlant ExtractsCognitive impairmentCurculiginis rhizomaEpimedii foliumHPLC–QQQ-MSPharmacokinetics

Identifiers

PMID39612119

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.