ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2025
Synthesis, characterization, and bioactivity of Cu(II), Fe(II), Co(II), Ni(II), and Mn(II) complexes with benzilmonoximethiocarbohydrazide-O-methoxybenzaldehyde: experimental and computational insights.
Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Acetylcholinesterase Inhibitory Co(II), Fe(II), Pd(II) and Ru(II) Complexes of a Tinoridine-based Schiff Base: Synthesis, Characterization and Antioxidant Evaluation.Applied biochemistry and biotechnology · 2026Article
- A coordinative partnership in tungsten chemistry: N-bound isothiocyanate and a tridentate pyrazolone-Schiff base in a hexacoordinate [WOJournal of computer-aided molecular design · 2026Article
- Benzilmonoximethiocarbohydrazide Schiff bases as multifunctional antimalarial and antioxidant scaffolds: synthesis, biological evaluation, and mechanistic insights.RSC advances · 2025Article
- Sustainable synthesis of Schiff base derivativesRSC advances · 2025Article
- Synergistic anti-inflammatory and anti-tb effects of Au-Pt-Cu nanofluids: experimental and computational insights.Future medicinal chemistry · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
In this study, a novel ligand, benzilmonoximethiocarbohydrazide-O-methoxybenzaldehyde (HBMToMB), was synthesized and subsequently complexed with Cu(II), Fe(II), Co(II), Ni(II), and Mn(II) ions. The metal complexes were comprehensively characterized using techniques such as NMR, IR, Mass Spectrometry, UV-Vis, elemental analysis (CHNS), and magnetic susceptibility measurements. The complexes exhibited superior antibacterial and antifungal activity compared to the free ligand. In addition, cytotoxicity was evaluated using the brine shrimp lethality bioassay, demonstrating significant activity. Computational studies, including molecular docking, DFT, and ADMET analysis, provided further insights into the compounds' binding affinities and electronic properties. These findings underscore the potential of these metal complexes as promising candidates for therapeutic applications, particularly in antimicrobial and anticancer therapies.
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Identifiers
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Registered trials
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