Evidence map›Paper›PMID 39612046›Full record

ReviewCurrent HIV/AIDS reports2024

Medicinal Plant and Traditional Knowledge-guided Strategies to Combat HIV Persistence.

Khumoekae Richard, Adi N R Poli, Kerstin Andrae-Marobela, Ian Tietjen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current HIV/AIDS reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Traditional Medicine Extracts ofInternational journal of molecular sciences · 2026
    Article
  3. mBio · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Khumoekae RichardThe Wistar Institute, Philadelphia, PA, USA.
Adi N R PoliThe Wistar Institute, Philadelphia, PA, USA.
Kerstin Andrae-MarobelaDepartment of Biological Sciences, University of Botswana, Gaborone, Botswana. marobelak@ub.ac.bw.
Ian TietjenThe Wistar Institute, Philadelphia, PA, USA. itietjen@wistar.org.

Funding

CIHR PJT-153057Penn Center for AIDS Research P30 AI 045008Sub-Saharan African Network for TB/HIV Research Excellence DEL-15-006W. W. Smith Charitable Trust A2301
6 · The paper itself

Abstract

purpose of reviewCombination antiretroviral therapy (cART) does not act on latent HIV reservoirs, and no latency-reversing agent (LRA) to date consistently reduces viral reservoirs in humans. In Sub-Saharan Africa and elsewhere, complementary and alternative medicines (CAM) are traditionally used to manage HIV/AIDS, including a subset with LRA properties. RECENT

findingsSeveral plants from the Euphorbiaceae and Thymelaeaceae families have been recently documented for traditional HIV/AIDS management and contain LRAs that function through protein kinase C activation. These CAM are increasingly validated in HIV-infected primary cells and humanized mice. Engagement with traditional health practitioners (THPs) which prioritizes data and benefits sharing can improve trust relations, build long-term collaborations, and advance mutual knowledge on these unique CAM. CAM used traditionally for HIV/AIDS management include LRAs already used by humans, but more study and collaboration with THPs are needed to understand their potential to support global cART-free HIV remission and cure efforts.

Indexed as

HIV InfectionsPlants, MedicinalVirus LatencyAnimalsAnti-HIV AgentsHIV-1HumansMedicine, TraditionalPhytotherapyAnti-HIV AgentsCommunity engagementLatency reversing agentsMedicinal plantsProtein Kinase C activationTraditional medicines

Identifiers

PMID39612046

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.