ArticleAsian Pacific journal of cancer prevention : APJCP2024
Identification of Molecular Subgroups of Muscle-Invasive Urothelial Bladder Cancer and Their Impact on Treatment Outcome.
Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Immunohistochemistry-Based Molecular Classification of Muscle-Invasive Bladder Urothelial Carcinoma: Survival Trends Across Molecular Subtypes.International journal of molecular sciences · 2026Article
- Prognostic Significance of CK5/6 and GATA3 Expression in Recurrent Urothelial Carcinoma.Cancers · 2025Article
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5 authors.
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Abstract
purposeNeoadjuvant chemotherapy (NACT) improves muscle-invasive bladder cancer (MIBC) survival. However, its efficacy is limited to a group of patients. This study explored CK5/6 and GATA3 for molecular subtyping and their prediction to response in patients with MIBC.
methodsThis is a prospective study that includes 50 patients with TCC bladder. All Patients received 4 cycles neoadjuvant gemcitabine/ cisplatin then guided to further treatment according to the response to NACT. Responders (CR & PR) went for CCRTH whereas non-responders (SD & PD) went surgery if resectable or second line chemotherapy if non-resectable. The baseline TUR pathology specimens were examined for histopathological feature and CK5/6 and GATA3 and divided into 4 molecular subgroups.
resultsThe patients were divided into four molecular subgroups: luminal (n=12/26.7%), basal (n=8/17.8%), double-positive (n=21/26.7%), and double-negative (n=4/8.9%). There was no clinicopathological difference seen among the 4 molecular subgroups. The PFS was higher in patients with GATA3 positive (24 months) than GATA3 negative (17 months). Yet, it did not reach a statistically significant value (P = 0.1605). On the other hand, PFS was not affected by either CK5/6 status or different molecular subgroups. The OS was better in the luminal subgroup than the basal (20.8 months versus 16.16 months respectively, While the double positive showed the highest OS of 26 months(P=0.0352).
conclusionGATA3 and CK5/6 IHC can classify MIBCs into four subtypes. These subtypes predicted treatment outcomes, however, were not correlated with the response to NACT. GATA3-positive tumors, luminal and double-positive subtypes tend to have higher OS and PFS. CK5/6 positivity did not impact the treatment outcome.
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