ArticleAmerican journal of physiology. Renal physiology2025
Genetic tools that target mechanoreceptors produce reliable labeling of bladder afferents and altered mechanosensation.
Article in American journal of physiology. Renal physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Different types of sensory nerve endings in the urinary bladder of mice arising from dorsal root ganglia (DRG) at the thoracolumbar region of vertebral column.Cell and tissue research · 2026Article
- Characterizing neuroma-like formation after tail docking in sheep.Research in veterinary science · 2026Article
- Differential immunoreactivity of alpha-smooth muscle actin in the mouse colon.Anatomical science international · 2026Article
- From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025Review
- Smooth muscle of the lower urinary tract: BK-RyR coupling in physiology and pathophysiology.Journal of muscle research and cell motility · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Mechanosensitive neurons are important sensors of bladder distention, but their role in urologic disease remains unclear. Our current knowledge about how disease alters bladder sensation comes from studies that focus primarily on peptidergic nociceptors, leaving our understanding of neuropeptide-negative mechanoreceptors incomplete. In this study, we found that a substantial proportion of neurofilament heavy (NFH)-positive A-fibers innervating the bladder was calcitonin gene-related peptide (CGRP)-negative, potentially representing uncharacterized mechanoreceptors. We then identified two genetic strategies that label mechanoreceptors in mouse skin and confirmed that they likewise label bladder afferents. Cre-mediated tdTomato reporter expression driven by tropomyosin receptor kinase B (
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