Evidence map›Paper›PMID 39611864›Full record

ReviewDevelopment (Cambridge, England)2024

Bioengineering vascularization.

Shira Landau, Sargol Okhovatian, Yimu Zhao, Chuan Liu, Amid Shakeri, Ying Wang, Kaitlyn Ramsay, Jennifer Kieda, Richard Jiang, Milica Radisic

Abstract readReview
In one paragraph

Review in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. 4D force patterning enables spatial control of angiogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shira LandauInstitute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, ON, Canada.ORCID 0000-0002-3514-3656
Sargol OkhovatianInstitute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, ON, Canada.
Yimu ZhaoInstitute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, ON, Canada.
Chuan LiuInstitute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, ON, Canada.
Amid ShakeriInstitute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, ON, Canada.
Ying WangInstitute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, ON, Canada.
Kaitlyn RamsayInstitute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, ON, Canada.
Jennifer KiedaInstitute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, ON, Canada.
Richard JiangInstitute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, ON, Canada.
Milica RadisicInstitute of Biomedical Engineering, University of Toronto, Toronto M5S 3G9, ON, Canada.ORCID 0000-0003-1249-4135

Funding

Engineering Vascularized Cardiac MuscleR01HL076485 · NHLBI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI Gordana Vunjak-Novakovic · 2005 to 2026
$9.2M
CIHR FDN-167274Natural Sciences and Engineering Research Council of Canada RGPIN 326982-10NHLBI NIH HHS R01 HL076485NIH HHS 2R01 HL076485
6 · The paper itself

Abstract

This Review explores the rapidly evolving field of bioengineered vasculature, a key area of focus in tissue engineering and regenerative medicine. The broad relevance of this topic is attributed to its impacts on a wide range of biological processes, enabling studies in tissue development, fundamental biology and drug discovery, and the applications in tissue engineering and regenerative medicine. We outline the design criteria for bioengineered vasculature and the methodologies for constructing these systems by self-assembly and in microfluidics, organs-on-a-chip and macroscale tubular systems that often rely on biofabrication approaches such as 3D printing. We discuss existing challenges in developing functional vasculature that closely mirrors its native equivalent, including achieving hierarchical branching with organ and vessel-specific endothelial and supporting cells, providing perusable vasculature within organoids and scaling the systems for implantation and direct vascular anastomosis.

Indexed as

Neovascularization, PhysiologicTissue EngineeringAnimalsBioengineeringHumansMicrofluidicsOrganoidsPrinting, Three-DimensionalRegenerative Medicine3D in vitro cultureBioengineeringVascular perfusionVasculature

Identifiers

PMID39611864
PMCPMC11698057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.