Evidence map›Paper›PMID 39611862›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2024

Striding beyond numbness: a non-randomized controlled study of an exercise program for breast cancer patients with chemotherapy-induced peripheral neuropathy.

Ruo-Lin Li, Jun-E Liu, Li-Xiao Bai, Ai-Ling Yang, Yu Liu, Fu-Yun Zhao, Lu Chen, Juan Liu

Abstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Addressing the Needs of Breast Cancer Survivors.Current oncology reports · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ruo-Lin LiSchool of Nursing, Capital Medical University, No. 10, Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
Jun-E LiuSchool of Nursing, Capital Medical University, No. 10, Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China. liujune66@ccmu.edu.cn.ORCID http://orcid.org/0000-0002-6843-9322
Li-Xiao BaiDepartment of Oncology, the Fifth Medical Center of PLA General Hospital, 100 West Middle Forth Ring Road, Fengtai District, Beijing, China.
Ai-Ling YangDepartment of Oncology, the Fifth Medical Center of PLA General Hospital, 100 West Middle Forth Ring Road, Fengtai District, Beijing, China.
Yu LiuSchool of Nursing, Capital Medical University, No. 10, Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
Fu-Yun ZhaoSchool of Nursing, Capital Medical University, No. 10, Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
Lu ChenSchool of Nursing, Capital Medical University, No. 10, Xitoutiao, You An Men Wai, Fengtai District, Beijing, 100069, China.
Juan LiuGalactophore Department, Capital Medical University Affiliated Beijing Shijitan Hospital, 10 Tieyi Rd, Haidian District, Beijing, China.

Funding

Beijing Municipal Natural Science Foundation 7222008
6 · The paper itself

Abstract

purposeTo investigate the effectiveness of a 13-week combined supervised and home-based exercise program in alleviating the symptoms of chemotherapy-induced peripheral neuropathy (CIPN) in patients with breast cancer (BC).

methodsIn this non-randomized controlled study, 77 patients with BC selected after applying the inclusion and exclusion criteria were allocated to the intervention (n = 37) or control (n = 40) group. Patients in the intervention group underwent a 13-week exercise program consisting of health education and hand and foot exercises combined with aerobic, resistance, and balance training, while those in the control group received usual care. The symptoms of CIPN were assessed at baseline (T0), post-intervention (T1), and 3 months post-intervention (T2). Physical fitness and finger flexibility were assessed at T0 and T1. A generalized estimating equation (GEE) model was used to analyze the repeated measures data.

resultsThe results of GEE showed a significant group effect, indicating significant intergroup differences in the total CIPN score and the dimensions of occurrence, severity, disruption, and frequency (all P < 0.05). Moreover, the two groups showed significant differences in finger flexibility and balance at T1 (all P < 0.05).

conclusionsThe exercise program was effective in alleviating the symptoms of CIPN and improved balance and finger dexterity in comparison with the control group. Randomized controlled trials with larger sizes are required to validate these findings.

Indexed as

Antineoplastic AgentsBreast NeoplasmsExercise TherapyPeripheral Nervous System DiseasesAdultAgedFemaleHumansHypesthesiaMiddle AgedPatient Education as TopicPhysical FitnessSeverity of Illness IndexAntineoplastic AgentsBreast cancerChemotherapy-induced peripheral neuropathyExerciseFinger flexibilityNursingSymptoms

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.