Evidence map›Paper›PMID 39611849›Full record

ArticleAging2024

When do the pathological signs become evident? Study of human mesenchymal stem cells in MDPL syndrome.

Spitalieri Paola, Guerrieri Lara, Murdocca Michela, Di Cesare Silvia, Maccaroni Serena, Pecorari Rosalba, Nardone Anna Maria, Candi Eleonora, Colasuonno Fiorella, Gori Giulia and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Spitalieri PaolaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Guerrieri LaraDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Murdocca MichelaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Di Cesare SilviaDepartment of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
Maccaroni SerenaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Pecorari RosalbaDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, Italy.
Nardone Anna MariaMedical Genetics Unit, Fondazione Policlinico Tor Vergata, Rome, Italy.
Candi EleonoraDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, Italy.
Colasuonno FiorellaDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, Rome, Italy.
Gori GiuliaMeyer Children’s Hospital IRCCS, Florence, Italy.
Traficante GiovannaMeyer Children’s Hospital IRCCS, Florence, Italy.
Novelli GiuseppeDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Sangiuolo FedericaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging syndromes are rare genetic disorders sharing the features of accelerated senescence. Among these, Mandibular hypoplasia, Deafness and Progeroid features with concomitant Lipodystrophy (MDPL; OMIM #615381) is a rare autosomal dominant disease due to a

Indexed as

Cellular SenescenceInduced Pluripotent Stem CellsMesenchymal Stem CellsAging, PrematureCell ProliferationDNA Polymerase IIIFemaleHumansLipodystrophyMaleMitochondriaProgeriaReactive Oxygen SpeciesDNA Polymerase IIIPOLD1 protein, humanReactive Oxygen SpeciesaginghiPSCsMDPL syndromeMSCsPOLD1 gene

Identifiers

PMID39611849
PMCPMC11723661

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.