ArticlemSystems2025
Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections.
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Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
8 citing papers in PubMed.
- Epistasis and co-adaptation in bacterial genome evolution.Nature reviews. Genetics · 2026Review
- Immunopathogenesis and Cytokine Pathways in Reactive Infectious Mucocutaneous Eruption (RIME) in Pediatric Population: Infectious Triggers and Molecular Insights.Clinical reviews in allergy & immunology · 2026Review
- Pediatric tracheostomy-associated respiratory infections: an evolving paradigm.Current opinion in pediatrics · 2026Review
- Immune cell disorder in viral pneumonia.Journal of translational medicine · 2026Review
- Host-microbiome archetypes differentiate infection from pathogen carriage in the human lower airway.Nature communications · 2026Article
- Artificial intelligence in the diagnosis and prognosis of pediatric bacterial pneumonia: current advances and challenges.Current opinion in pediatrics · 2026Review
- Explainable machine learning for the early differentiation of pediatric bronchopneumonia using routine laboratory parameters.PloS one · 2026Article
- Analysis of blood proteome in influenza-infected patients reveals new insights into the host response signatures distinguishing mild severe infections.Frontiers in immunology · 2025Article
Corrections and comments
- Update of
Authors and funding
22 authors.
Emily Lydon *Department of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0003-3510-6254
Christina M Osborne *Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-7452-4734
Brandie D WagnerDepartment of Biostatistics and Informatics, University of Colorado, Colorado School of Public Health, Aurora, Colorado, USA.
Lilliam AmbroggioSections of Emergency Medicine and Hospital Medicine, Children's Hospital Colorado, Aurora, Colorado, USA.
J Kirk HarrisDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado, USA.
Ron ReederDepartment of Pediatrics, University of Utah, Salt Lake City, Utah, USA.
Todd C CarpenterDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado, USA.
Aline B MadduxDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado, USA.
Matthew K LeroueDepartment of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado, USA.
Nadir YehyaDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Joseph L DeRisiChan Zuckerberg Biohub, San Francisco, California, USA.
Mark W HallDepartment of Pediatrics, Nationwide Children's Hospital, Columbus, Ohio, USA.
Athena F ZuppaDepartment of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Joseph CarcilloDepartments of Pediatrics and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Kathleen MeertDepartment of Pediatrics, Children's Hospital of Michigan, Central Michigan University, Detroit, Michigan, USA.
Anil SapruDepartment of Pediatrics, University of California Los Angeles, Los Angeles, California, USA.
Murray M PollackDepartment of Pediatrics,, Children's National Medical Center and George Washington School of Medicine and Health Sciences, Washington, DC, USA.
Patrick McQuillenDepartment of Pediatrics, University of California San Francisco, San Francisco, California, USA.
Daniel A NottermanDepartment of Molecular Biology, Princeton University, Princeton, New Jersey, USA.
Charles R LangelierDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-6708-4646
Peter M MouraniDepartment of Pediatrics, Critical Care, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, Arkansas, USA.ORCID 0000-0002-1829-3775
Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN)
Funding
CPCCRN PRECISE SupplementPL1HD105462 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Jonathan Michael Dean · 2021 to 2026
$17.5MBIOLOGY OF INFECTIOUS DISEASES TRAINING PROGRAMT32AI007641 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY · 2000 to 2026
$6.9MInflammation Phenotypes in Pediatric Sepsis Induced Multiple Organ Failure RenewalR01GM108618 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOSEPH A CARCILLO · 2014 to 2026
$5.4MThe Microbiome, Virome and Host Responses Preceding Ventilator-Associated PneumonR01HL124103 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MOURANI, PETER M, SONTAG, MARCI K · 2014 to 2017
$2.7MCollaborative Pediatric Critical Care Research Network (CPCCRN) at Children's NationalUG1HD049981 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI POLLACK, MURRAY MICHAEL, WESSEL, DAVID LLOYD · 2015 to 2020
$1.8MPediatric Critical Care Research Network at Children's Hospital of PhiladelphiaUG1HD063108 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI BERG, ROBERT ALLEN, ZUPPA, ATHENA F. · 2015 to 2020
$1.7MCollaborative Research to Validate Biomarkers of Pediatric ARDSUG1HD083166 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCQUILLEN, PATRICK SEAN, SAPRU, ANIL · 2015 to 2020
$1.6MIntegrated Host/Microbe Metagenomics to Improve Lower Respiratory Tract Infection Diagnosis in Critically Ill ChildrenR01HL155418 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LANGELIER, CHARLES · 2021 to 2024
$1.6MRenewal Application for the Childrens Hospital of Pittsburgh Collaborative Pediatric Critical Care Research Network SiteUG1HD049983 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CARCILLO, JOSEPH A · 2015 to 2020
$1.6MCollaborative Pediatric Critical Care Research NetworkUG1HD050096 · NICHD · WAYNE STATE UNIVERSITY · PI MEERT, KATHLEEN L. · 2015 to 2020
$1.6MIntegrated Host/Microbe (IHM) Metagenomics of the Lower Airway to Diagnose PediatricRespiratory Infections, Identify Etiologic Pathogens, and Predict OutcomesR01AI182308 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Charles Langelier, Peter Michael Mourani · 2025 to 2026
$1.6MCollaborative Network Study of Airway Microbiome and Host Responses in Pediatric Respiratory FailureUG1HD083171 · NICHD · UNIVERSITY OF COLORADO DENVER · PI CARPENTER, TODD C · 2015 to 2020
$1.5MChan Zuckerberg BiohubHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL124103HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) 5R01HL155418HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) UG1HD083171NHLBI NIH HHS K23 HL138461NHLBI NIH HHS R01 HL124103NHLBI NIH HHS R01 HL155418NIAID NIH HHS R01 AI182308NIAID NIH HHS T32 AI007641NICHD NIH HHS PL1 HD105462NICHD NIH HHS UG1 HD049981NICHD NIH HHS UG1 HD049983NICHD NIH HHS UG1 HD050096NICHD NIH HHS UG1 HD063108NICHD NIH HHS UG1 HD083166NICHD NIH HHS UG1 HD083170NICHD NIH HHS UG1 HD083171NIGMS NIH HHS R01 GM108618
Abstract
Viral lower respiratory tract infection (vLRTI) is a leading cause of hospitalization and death in children worldwide. Despite this, no studies have employed proteomics to characterize host immune responses to severe pediatric vLRTI in both the lower airway and systemic circulation. To address this gap, gain insights into vLRTI pathophysiology, and test a novel diagnostic approach, we assayed 1,305 proteins in tracheal aspirate (TA) and plasma from 62 critically ill children using SomaScan. We performed differential expression (DE) and pathway analyses comparing vLRTI (
Indexed as
ProteomeProteomicsRespiratory Tract InfectionsVirus DiseasesBiomarkersChildChild, PreschoolFemaleHumansInfantMaleViral LoadBiomarkersProteomeco-infectionhost responseLRTIpneumoniaproteomicsrespiratory virusesviral pneumonia
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.