Evidence map›Paper›PMID 39611618›Full record

ArticleAmerican journal of physiology. Cell physiology2025

Julia Ritterhoff, Timothy McMillen, Hanna Foundas, Roland Palkovacs, Gernot Poschet, Arianne Caudal, Yaxin Liu, Patrick Most, Matthew Walker, Rong Tian

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julia RitterhoffDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington, Seattle, Washington, United States.ORCID 0000-0002-3419-4830
Timothy McMillenDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington, Seattle, Washington, United States.
Hanna FoundasMolecular and Translational Cardiology, Department of Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany.
Roland PalkovacsCentre for Organismal Studies, Metabolomics Core Technology Platform (MCTP), Heidelberg University, Heidelberg, Germany.
Gernot PoschetCentre for Organismal Studies, Metabolomics Core Technology Platform (MCTP), Heidelberg University, Heidelberg, Germany.ORCID 0000-0002-5344-0865
Arianne CaudalDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington, Seattle, Washington, United States.ORCID 0000-0001-9836-9436
Yaxin LiuDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington, Seattle, Washington, United States.ORCID 0000-0002-0981-5746
Patrick MostMolecular and Translational Cardiology, Department of Internal Medicine III, University Hospital Heidelberg, Heidelberg, Germany.
Matthew WalkerDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington, Seattle, Washington, United States.
Rong TianDepartment of Anesthesiology and Pain Medicine, Mitochondria and Metabolism Center, University of Washington, Seattle, Washington, United States.ORCID 0000-0002-3676-3830

Funding

Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Fatty acid oxidation suppresses cardiac hypertrophyR01HL129510 · NHLBI · UNIVERSITY OF WASHINGTON · PI TIAN, RONG · 2015 to 2018
$2.8M
Mitochondrial function and glycolytic switch in pathological cardiac hypertrophyR01HL142628 · NHLBI · UNIVERSITY OF WASHINGTON · PI TIAN, RONG · 2018 to 2021
$2.4M
American Heart Association (AHA) 20PRE35120126American Heart Association (AHA) 930223American Heart Association-American Stroke Association 930223Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) 81X3500143Deutsches Zentrum für Herz-Kreislaufforschung (DZHK) 81Z0500101HHS | National Institutes of Health (NIH) HL-129510HHS | National Institutes of Health (NIH) HL-142628NHLBI NIH HHS R01 HL129510NHLBI NIH HHS R01 HL142628NIDDK NIH HHS P30 DK017047
6 · The paper itself

Abstract

The TCA cycle serves as a central hub to balance catabolic and anabolic needs of the cell, where carbon moieties can either contribute to oxidative metabolism or support biosynthetic reactions. This differential TCA cycle engagement for glucose-derived carbon has been extensively studied in cultured cells, but the fate of fatty acid (FA)-derived carbons is poorly understood. To fill the knowledge gap, we have developed a strategy to culture cells with long-chain FAs without altering cell viability. By tracing

Indexed as

Carbon IsotopesCell ProliferationCitric Acid CycleFatty AcidsOxidation-ReductionAnimalsCitric AcidEnergy MetabolismGlucoseHumansMiceMitochondriaOxygen ConsumptionCarbon IsotopesCitric AcidFatty AcidsGlucose13C stable isotope tracingFAOoxygen consumption rateTCA cycle

Identifiers

PMID39611618
PMCPMC12169336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.