Evidence map›Paper›PMID 39611587›Full record

ReviewEssays in biochemistry2024

Characteristics of phage-plasmids and their impact on microbial communities.

Ruweyda Sayid, Anne W M van den Hurk, Daniela Rothschild-Rodriguez, Hilde Herrema, Patrick A de Jonge, Franklin L Nobrega

Abstract readReview
In one paragraph

Review in Essays in biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Characterization of a novel phage-plasmid vB_EcoM_ED targeting multidrug-resistant Escherichia coli isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Article
  3. The extended mobility of plasmids.Nucleic acids research · 2025
    Review
  4. Review
  5. The new age of the phage.Essays in biochemistry · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ruweyda Sayid *School of Biological Sciences, University of Southampton, Southampton, UK.
Anne W M van den Hurk *Departments of Internal and Experimental Vascular Medicine, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam; the Netherlands.
Daniela Rothschild-Rodriguez *School of Biological Sciences, University of Southampton, Southampton, UK.
Hilde HerremaDepartments of Internal and Experimental Vascular Medicine, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam; the Netherlands.
Patrick A de JongeDepartments of Internal and Experimental Vascular Medicine, Amsterdam UMC, Location AMC, University of Amsterdam, Amsterdam; the Netherlands.
Franklin L NobregaSchool of Biological Sciences, University of Southampton, Southampton, UK.ORCID 0000-0002-8238-1083

Funding

Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers (ACS) PhD fellowshipAmsterdam University Fund AUF 5188Biotechnology and Biological Sciences Research Council (BBSRC) BB/T008768/1Bowel Research UK (BRUK)Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) Aspasia premium (015.017.050)University of Southampton (University of Southampton UK) Black Futures Research Studentship
6 · The paper itself

Abstract

Bacteria host various foreign genetic elements, most notably plasmids and bacteriophages (or phages). Historically, these two classes were seen as separate, but recent research has shown considerable interplay between them. Phage-plasmids (P-Ps) exhibit characteristics of both phages and plasmids, allowing them to exist extrachromosomally within bacterial hosts as plasmids, but also to infect and lyse bacteria as phages. This dual functionality enables P-Ps to utilize the modes of transmission of both phage and plasmids, facilitating the rapid dissemination of genetic material, including antibiotic resistance and virulence genes, throughout bacterial populations. Additionally, P-Ps have been found to encode toxin-antitoxin and CRISPR-Cas adaptive immune systems, which enhance bacterial survival under stress and provide immunity against other foreign genetic elements. Despite a growing body of literature on P-Ps, large gaps remain in our understanding of their ecological roles and environmental prevalence. This review aims to synthesise existing knowledge and identify research gaps on the impacts of P-Ps on microbial communities.

Indexed as

BacteriaBacteriophagesMicrobiotaPlasmidsCRISPR-Cas SystemsAntimicrobial resistance (AMR)BacteriohagesHorizontal Gene Transfer (HGT)MicrobiomePhage-Plasmids (P-Ps)Plasmids

Identifiers

PMID39611587
PMCPMC11652158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.