Evidence map›Paper›PMID 39611552›Full record

ArticleAnnals of medicine2024

Development and validation of the prediction model based on autophagy-associated genes in bronchopulmonary dysplasia.

Qingqing Liu, Meiyu Zhang, Qingqing Xiang, Yi He, Fang Li

Abstract readValidation Study
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Article in Annals of medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Qingqing LiuDepartment of Pediatrics, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Meiyu ZhangDepartment of Neonatology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing, China.
Qingqing XiangDepartment of Pediatrics, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Yi HeDepartment of Pediatrics, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Fang LiDepartment of Pediatrics, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBronchopulmonary dysplasia (BPD) is the most common chronic respiratory disease among preterm infants. Owing to the limitations in current diagnostic methods, developing a predictive model for BPD is crucial.

methodsUsing 243 autophagy-associated genes and dataset GSE32472, differential expression of autophagy-associated genes was identified at postnatal days 5, 14, and 28 between BPD patients and controls. LASSO and multivariate logistic regression analyses were performed to screen for diagnostic prediction genes. Receiver Operating Characteristic, Harrell's concordance index, and decision curve analysis (DCA) were used to evaluate the diagnostic prediction model in GSE32472 and GSE220135. A BPD mouse model was constructed and qRT-PCR and Western blot were used to verify gene expression in lung tissue.

resultsBased on

conclusionsWe constructed and validated a diagnostic prediction model for BPD based on WIPI1, TOMM70A, BAG3, and PRKCQ. These four genes may influence BPD development by regulating immune responses and immune cells.

Indexed as

AutophagyBronchopulmonary DysplasiaDisease Models, AnimalAdaptor Proteins, Signal TransducingAnimalsApoptosis Regulatory ProteinsFemaleHumansInfant, NewbornInfant, PrematureLungMaleMiceROC CurveAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsautophagyBronchopulmonary dysplasiaprediction model

Identifiers

PMID39611552
PMCPMC11610359

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