ArticleVeterinary medicine and science2025
Oxidative Stress Biomarkers and Metabolic Parameters in Healthy Holstein Dairy Cows and Cows With Left Displacement Abomasum During the Transitional Period.
Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Abomasal Disorders in Dairy Cows During the Transition Period: Interconnected Risk Factors and Repercussions on Health and Culling Rate.Animals : an open access journal from MDPI · 2026Review
- A case report of multiple complex digestive system diseases in a cow in the dry period.Veterinary research communications · 2026Article
- Diet-Microbiome-Redox Interactions and Oxidative Stress Biomarkers in Livestock: Computational and Spatial Perspectives for Translational Health and Production.International journal of molecular sciences · 2026Review
- Predicting the onset of left displaced abomasum using behavioral changes measured by small 3D acceleration sensors attached to a cow collar.The Journal of veterinary medical science · 2026Article
- Current Understanding of Bovine Ketosis: From Molecular Basis to Farm-Level Management.Animals : an open access journal from MDPI · 2025Review
- Rutin Attenuates Oxidative Stress Responses and Hepatocyte Metabolomics in β-Hydroxybutyric Acid-Induced Hepatocyte Injury in Calves.International journal of molecular sciences · 2025Article
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7 authors.
Funding
Abstract
backgroundDuring the transitional period, dairy cows experience oxidative stress and are more susceptible to diseases, including left displacement of the abomasum (LDA).
objectivesThis study aimed to compare oxidative stress biomarker levels in cows with LDA to those in healthy conditions and investigate the associations between predictive metabolites linked to LDA and oxidative stress biomarkers.
methodsIn this case-control study, 400 healthy multiparous Holstein cows were matched for lactation number, milk production and calving date. Blood samples were collected at four time points: 21 and 7 days before, as well as 7 and 21 days after parturition from all animals. During the observation period, seven cows diagnosed with LDA in the main population, and seven healthy cows were randomly selected as controls for the comparison of oxidative stress, liver enzymes and metabolic parameters. Analysis of blood parameters utilized repeated measures ANOVA, and the degree of relationship between oxidative stress biomarkers and other measured parameters was assessed using Pearson correlations.
resultsThe LDA group exhibited significantly higher levels of urea, blood urea nitrogen (BUN), gamma-glutamyl transferase, glucose, cholesterol, triglyceride (TAG), β-hydroxybutyric acid (BHBA), aspartate aminotransferase (AST), sorbitol dehydrogenase, serum amyloid A (SAA), chloride, sodium, potassium, total antioxidant capacity (TAC) and malondialdehyde (MDA) compared to the control cows (p < 0.05). Positive correlations were observed among BUN, glucose, TB, AST, SAA, BHBA, TAG and MDA. Conversely, these parameters displayed negative correlations with TAC. Negative correlations were found among chloride, sodium, potassium, calcium, phosphorus and MDA, whereas positive correlations were observed with TAC.
conclusionsThese findings highlight the elevated level of oxidative stress and compromised antioxidant defence in cows with LDA and the intricate interplay among oxidative stress, metabolic parameters and liver enzymes.
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