Evidence map›Paper›PMID 39611273›Full record

ArticleMacromolecular rapid communications2025

Cyclooctyne End-Functionalized Poly(morpholine-2,5-dione)s.

Johanna Schreiber, Natalie E Göppert, Leanne M Stafast, Christine Weber, Ulrich S Schubert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Macromolecular rapid communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Cyclooctyne End-Functionalized Poly(morpholine-2,5-dione)s.Macromolecular rapid communications · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Johanna SchreiberLaboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.
Natalie E GöppertLaboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.
Leanne M StafastLaboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.
Christine WeberLaboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.ORCID https://orcid.org/0000-0003-0712-5255
Ulrich S SchubertLaboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich Schiller University Jena, Humboldtstr. 10, 07743, Jena, Germany.

Funding

Deutsche Forschungsgemeinschaft 316213987Deutsche Forschungsgemeinschaft SFB1278Thüringer Aufbaubank 2016 IZN 0009
6 · The paper itself

Abstract

The cyclooctyne-functionalized alcohol (1R,8S,9S)-bicyclo-[6.1.0]non-4-yn-9-ylmethanol (BCN-OH) is applied as initiator for the organo-catalyzed ring-opening polymerization (ROP) of morpholine-2,5-diones based on the l-amino acids valine, isoleucine, and phenylalanine. The ROP is catalyzed by a binary system of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) and 1-(3,5-bis(trifluoromethyl)phenyl)-3-cyclohexylthiourea (TU) applying a feed ratio of [M]/[I]/[DBU]/[TU] of 100/1/1/10. Kinetic studies reveal that BCN-OH is capable to initiate the polymerization of morpholine-2,5-diones, which proceed in a controlled manner until monomer conversions of 80%. Characterization by means of

Indexed as

CyclooctanesMorpholinesPolymersCatalysisMolecular StructurePolymerizationCyclooctanesmorpholineMorpholinesPolymersclick chemistrymorpholine‐2,5‐dionepolydepsipeptidepoly(ester amide)ring‐opening polymerizationstrain‐promoted azide‐alkyne cycloaddition (SPAAC)

Identifiers

PMID39611273
PMCPMC11800061

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.