ArticleCirculation. Genomic and precision medicine2024
Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases.
Article in Circulation. Genomic and precision medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Association of long-term depressive burden with incident cardiometabolic multimorbidity: a prospective study in middle-aged and older adults across three continents.Journal of global health · 2026Article
- Effects of Schizophrenia, Bipolar Disorder, and Depression on Cardiopulmonary and Abdominal Organ Structure.Biological psychiatry global open science · 2026Article
- Genetic perspectives on the comorbidity of anxiety and mood disorders with cardiovascular disease.Nature cardiovascular research · 2026Review
- Sex Differences in Self-Rated Health and Cardiovascular Disease Events.JAMA network open · 2026Article
- Applying machine-learning and deep-learning to predict depression from brain MRI and identify depression-related brain biology.Translational psychiatry · 2026Article
- Systemic Inflammation at the Crossroad of Major Depressive Disorder and Comorbidities: A Narrative Review.International journal of molecular sciences · 2025Review
- Sex-Specific Polygenic Risk Scores and Replication in a Model-Free Analysis of Schizophrenia Data.Genes · 2025Article
- Depression and Coronary Artery Disease-Where We Stand?Journal of clinical medicine · 2025Review
- The mediating roles of obesity indicators and serum albumin in the association of DEET exposure with depression and sleep disorders in adults: evidence from NHANES 2007-2016.BMC public health · 2025Article
- Cardiovascular disease and depression: a bidirectional relationship and its clinical implications.Frontiers in psychiatry · 2025Review
- Major Depressive Disorder Impacts Peripheral Artery Disease Risk Through Intermediary Risk Factors.Journal of the American Heart Association · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThough epidemiological studies show increased cardiovascular disease (CVD) risks among individuals with psychiatric disorders, findings on sex differences in comorbidity have been inconsistent.
methodsThis genetic epidemiology study examined the sex-specific association between the genetic risk of 3 psychiatric disorders (major depression [MD], schizophrenia, and bipolar disorder), estimated using polygenic scores (PGSs), and risks of 3 CVDs (atrial fibrillation [AF], coronary artery disease [CAD], and heart failure [HF]) in 345 169 European-ancestry individuals (UK Biobank), with analyses replicated in an independent BioVU cohort (n=49 057). Mediation analysis was conducted to determine whether traditional CVD risk factors could explain any observed sex difference.
resultsIn the UK Biobank, a 1-SD increase in PGS
conclusionsGenetic predisposition to MD confers a greater risk of CVDs in females versus males, even in the absence of any depression diagnosis. This study warrants further investigation into whether genetic predisposition to depression could be useful for improving cardiovascular risk prediction, especially in women.
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