Evidence map›Paper›PMID 39611158›Full record

ArticleFrontiers in immunology2024

Unbiased immunome characterisation correlates with COVID-19 mRNA vaccine failure in immunocompromised adults.

Juan H-Vázquez, Paloma Cal-Sabater, Elisa Arribas-Rodríguez, Aida Fiz-López, Candido Perez-Segurado, Álvaro Martín-Muñoz, Ángel De Prado, Marina Perez Mazzali, Carolina G de Castro, Alejandro G Del Hierro and 36 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Juan H-Vázquez *Mucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Paloma Cal-Sabater *Mucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Elisa Arribas-RodríguezMucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Aida Fiz-LópezMucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Candido Perez-SeguradoMucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Álvaro Martín-MuñozFlow Cytometry Facility, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Ángel De PradoMucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Marina Perez MazzaliMucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Carolina G de CastroMucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Alejandro G Del HierroMucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Ignacio de la Fuente GracianiDepartment of Hematology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Sonia Pérez GonzálezDepartment of Hematology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Sara GutiérrezInternal Medicine Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Pablo TelleríaInternal Medicine Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Cristina NovoaInternal Medicine Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Silvia Rojo RelloMicrobiology and Inmunology Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Antonio Garcia-BlesaMucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Rosa SedanoInternal Medicine Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Ana María Martínez GarcíaMicrobiology and Inmunology Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Sonsoles Garcinuño PérezMicrobiology and Inmunology Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Marta Domínguez-GilMicrobiology Department, Hospital Universitario Río Hortega, Valladolid, Spain.
Cristina Hernán GarcíaServicio de Medicina Preventiva, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Ma Mercedes GuerraServicio de Medicina Preventiva, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Eduardo Muñoz-SánchezUnidad de Cuidados Paliativos del Hospital Universitario Río Hortega, Valladolid, Spain.
Cristina Barragan-PérezUnidad de Cuidados Paliativos del Hospital Universitario Río Hortega, Valladolid, Spain.
Soraya Diez MoralesUnidad de Cuidados Paliativos del Hospital Universitario Río Hortega, Valladolid, Spain.
Oriana Casazza DonnarummaUnidad de Cuidados Paliativos del Hospital Universitario Río Hortega, Valladolid, Spain.
Daniel Ramos PolloUnidad de Cuidados Paliativos del Hospital Universitario Río Hortega, Valladolid, Spain.
Natalia Santamarta SollaUnidad de Cuidados Paliativos del Hospital Universitario Río Hortega, Valladolid, Spain.
Paula Ma Álvarez ManzanaresUnidad de Cuidados Paliativos del Hospital Universitario Río Hortega, Valladolid, Spain.
Sara BravoDepartment of Hematology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Cristina García AlonsoDepartment of Hematology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Luis Alberto Avendaño FernándezServicio de Prevención de Riesgos Laborales, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Jenifer Gay AlonsoResidencia y Centro de Día ORPEA Valladolid, Valladolid, Spain.
José A GarroteMucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
Eduardo ArranzMucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
José María EirosMicrobiology Department, Hospital Universitario Río Hortega, Valladolid, Spain.
Fernando Rescalvo SantiagoServicio de Prevención de Riesgos Laborales, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Carolina Quevedo VillegasServicio de Prevención de Riesgos Laborales, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Eduardo TamayoUnidad Investigación, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Antonio OrduñaMicrobiology and Inmunology Unit, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Carlos DueñasInternal Medicine Department, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
María Jesús PeñarrubiaDepartment of Hematology, Hospital Clínico Universitario de Valladolid, Valladolid, Spain.
Sara Cuesta-Sancho *Mucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.
María Montoya *Viral Immunology, Therapies and Vaccines Lab, Centro de Investigaciones Biológicas Margarita Salas (CIB), Madrid, Spain.
David Bernardo *Mucosal Immunology Lab, Unit of Excellence Institute of Biomedicine and Molecular Genetics of Valladolid (IBGM, University of Valladolid-CSIC), Valladolid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Coronavirus disease 2019 (COVID-19) affects the population unequally, with a greater impact on older and immunosuppressed people. Methods: Hence, we performed a prospective experimental cohort study to characterise the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination in immune-compromised patients (older adults and oncohaematologic patients), compared with healthy counterparts, based on deep characterisation of the circulating immune cell subsets. Results and discussion: While acquired humoral and cellular memory did not predict subsequent infection 18 months after full vaccination, spectral and computational cytometry revealed several subsets within the CD8

Indexed as

COVID-19COVID-19 VaccinesImmunocompromised HostSARS-CoV-2AdultAgedAged, 80 and overCD8-Positive T-LymphocytesFemaleHumansImmunologic MemoryMaleMiddle AgedmRNA VaccinesProspective StudiesVaccinationCOVID-19 VaccinesmRNA Vaccinescomputational cytometryCOVID-19immunocompromised adultimmunomevaccine failure

Identifiers

PMID39611158
PMCPMC11602488

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.