ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Associations between depression and anxiety in midlife and dementia more than 30 years later: The HUNT Study.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Longitudinal associations of psychological distress with subsequent cognitive decline and dementia: a multi-cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Mental health symptoms as preclinical indicators of dementia: a Whitehall II cohort study.medRxiv : the preprint server for health sciences · 2026Article
- Validation and Evaluation of the Chinese Version of the Healthy Aging Questionnaire in Hong Kong.Journal of aging research · 2026Article
- The Glymphatic System and Diaphragmatic Dysfunction in Patients with Chronic Obstructive Pulmonary Disease and Chronic Heart Failure: The Importance of Inspiratory Rehabilitation Training.Journal of cardiovascular development and disease · 2025Review
- Associations between depression and anxiety in midlife and dementia more than 30 years later: The HUNT Study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
10 authors.
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Abstract
introductionIt is unclear how midlife depression and anxiety affect dementia risk. We examined this in a Norwegian cohort followed for 30 years.
methodsDementia status at age 70+ in the fourth wave of the Trøndelag Health Study (HUNT4, 2017-2019,
resultsDementia at HUNT4 was associated with higher case prevalence at all waves, from 1.9 percentage points (pp) (95% CI: 0.1-3.7) higher at HUNT1 to 7.6 pp (95% CI: 5.7-9.6) higher at HUNT4. DISCUSSION: Our findings show that depression and anxiety was more common more than 30 years before dementia onset in those who later developed dementia. Highlights: Older individuals with dementia had a higher prevalence of mixed anxiety- and depressive symptoms (A + D), both concurrently with and more than three decades prior to their dementia diagnosis.Older individuals with dementia had higher levels of anxiety, both concurrently and up to two decades prior to their dementia diagnosis.Depressive symptoms increased by time among those who developed dementia, but not among others.Results were similar for all cause dementia, Alzheimer's disease, and other types of dementia; however, for vascular dementia, the difference was not significant until dementia was present.
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