Evidence map›Paper›PMID 39611007›Full record

ArticleInternational journal of nanomedicine2024

Enhanced Efficacy of Some Antibiotics in the Presence of Silver Nanoparticles Against Clinical Isolate of

Hafez Al-Momani, Hadeel Albalawi, Dua'a Al Balawi, Khaled M Khleifat, Iman Aolymat, Saja Hamed, Borhan Aldeen Albiss, Ashraf I Khasawneh, Ola Ebbeni, Ayman Alsheikh and 3 more

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hafez Al-MomaniDepartment of Microbiology, Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa, 13133, Jordan.ORCID 0000-0003-2119-0811
Hadeel AlbalawiFaculty of Applied Medical Sciences, The Hashemite University, Zarqa, 13133, Jordan.
Dua'a Al BalawiFaculty of Applied Medical Sciences, The Hashemite University, Zarqa, 13133, Jordan.
Khaled M KhleifatBiology Department, College of Science, Mutah University, Mutah, Karak, 61710, Jordan.
Iman AolymatDepartment of Anatomy, Physiology and Biochemistry, Faculty of Medicine, The Hashemite University, Zarqa, 13133, Jordan.ORCID 0000-0002-1231-1071
Saja HamedDepartment of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, The Hashemite University, Zarqa, 13133, Jordan.ORCID 0000-0001-5908-5676
Borhan Aldeen AlbissNanotechnology Institute, Jordan University of Science & Technology, Irbid, 22110, Jordan.
Ashraf I KhasawnehDepartment of Microbiology, Pathology and Forensic Medicine, Faculty of Medicine, The Hashemite University, Zarqa, 13133, Jordan.
Ola EbbeniDepartment of Pharmacology and Public Health, Faculty of Medicine, The Hashemite University, Zarqa, 13133, Jordan.
Ayman AlsheikhDepartment of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Zarqa University, Zarqa, 13110, Jordan.
AbdelRahman M ZueterDepartment of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, The Hashemite University, Zarqa, 13133, Jordan.ORCID 0000-0001-9960-4290
Jeffrey Peter PearsonBiosciences Institute, Newcastle University Medical School, Newcastle Upon Tyne, UK.
Christopher WardTranslational and Clinical Research Institute, Newcastle University Medical School, Newcastle Upon Tyne, NE2 4HH UK.ORCID 0000-0002-6954-9611

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Given the increasing frequency of drug-resistant bacteria and the limited progress in developing new antibiotics, it is necessary to explore new methods of combating microbial infections. Nanoparticles, particularly silver nanoparticles (Ag-NPs), have shown exceptional antibacterial characteristics; however, elevated concentrations of Ag-NPs can produce noticeable levels of toxicity in mammalian cells. Aim: This study examined the potential synergistic effect of combining a low dosage of Ag-NPs and anti-pseudomonas drugs against Methods: The Ag-NPs were chemically produced by utilizing a seed extract from Results: The biosynthesized Ag-NPs were uniformly spherical and measured around 15 nm in size. When combined with antibiotics, Ag-NP produced statistically significant reductions in the amount of antibiotics required to completely prevent Conclusion: The findings revealed that combining Ag-NPs with antibiotics was more effective than using Ag-NPs or antibiotics in isolation and that combinations of Ag-NPs and antimicrobial agents displayed synergistic activity against the majority of strains assessed.

Indexed as

Anti-Bacterial AgentsCystic FibrosisDrug SynergismMetal NanoparticlesMicrobial Sensitivity TestsPseudomonas aeruginosaPseudomonas InfectionsSilverHumansPlant ExtractsAnti-Bacterial AgentsPlant ExtractsSilverantibiotic resistancebiofilmcystic fibrosis CFnanoparticlesPseudomonas aeruginosasilver nanoparticlessynergy

Identifiers

PMID39611007
PMCPMC11602434

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.