Evidence map›Paper›PMID 39610727›Full record

ArticleJACS Au2024

Microfluidics-Based Ionic Catch and Release Oligosaccharide Synthesis (ICROS-Microflow) to Expedite Glycosylation Chemistry.

Yao-Yao Zhang, Mattia Ghirardello, Ryan Williams, Adrian Silva Diaz, Javier Rojo, Josef Voglmeir, Javier Ramos-Soriano, M Carmen Galan

Erratum issuedAbstract read
In one paragraph

Article in JACS Au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Yao-Yao ZhangSchool of Chemistry, Cantock's Close, University of Bristol, Bristol BS8 1TS, U.K.
Mattia GhirardelloSchool of Chemistry, Cantock's Close, University of Bristol, Bristol BS8 1TS, U.K.ORCID https://orcid.org/0000-0002-2855-4801
Ryan WilliamsSchool of Chemistry, Cantock's Close, University of Bristol, Bristol BS8 1TS, U.K.
Adrian Silva DiazInstituto de Investigaciones Químicas, CSIC-Universidad de Sevilla, Avenue Américo Vespucio 49, Seville 41092, Spain.
Javier RojoInstituto de Investigaciones Químicas, CSIC-Universidad de Sevilla, Avenue Américo Vespucio 49, Seville 41092, Spain.ORCID https://orcid.org/0000-0003-3173-3437
Josef VoglmeirGlycomics and Glycan Bioengineering Research Center, College of Food Science and Technology, Nanjing Agricultural University, 1 Weigang, 210095 Nanjing, China.ORCID https://orcid.org/0000-0002-4096-4926
Javier Ramos-SorianoInstituto de Investigaciones Químicas, CSIC-Universidad de Sevilla, Avenue Américo Vespucio 49, Seville 41092, Spain.ORCID https://orcid.org/0000-0002-3054-0679
M Carmen GalanSchool of Chemistry, Cantock's Close, University of Bristol, Bristol BS8 1TS, U.K.ORCID https://orcid.org/0000-0001-7307-2871

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A continuous microfluidic glycosylation strategy that requires no chromatography between steps and significantly expedites glycosylation chemistry is described. This practical approach incorporates the advantages of imidazolium-based chromatography-free purification and in situ mass spectrometry reaction monitoring to achieve fast reaction optimization and shorter reaction times. We demonstrate the utility of this strategy in the synthesis of a series of glycoside targets, including an α-(1,6)-trimannoside and a branched Man

Identifiers

PMID39610727
PMCPMC11600195

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.