Bioinspired Ion Host with Buried and Consecutive Binding Sites for Controlled Ion Dislocation.

Wenjie Zhu, Zhenchuang Xu, Wei Zhang, Qi Jia, Haoliang Hao, Yucheng Gu, Yanchuan Zhao

Abstract read

In one paragraph

Article in JACS Au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wenjie ZhuKey Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.

Zhenchuang XuKey Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.

Wei ZhangKey Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.

Qi JiaKey Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.

Haoliang HaoKey Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.

Yucheng GuJealott's Hill International Research Centre, Syngenta, Bracknell, Berkshire RG42 6EY, U.K.ORCID https://orcid.org/0000-0002-6400-6167

Yanchuan ZhaoKey Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.ORCID https://orcid.org/0000-0002-2903-4218

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents a bioinspired ion host featuring continuous binding sites arranged in a tunnel-like structure, closely resembling the selectivity filter of natural ion channels. Our investigation reveals that ions traverse these sites in a controlled, sequential manner due to the structural constraints, effectively mimicking the ion translocation process observed in natural channels. Unlike systems with open binding sites, our model facilitates sequential ion recognition state transitions, enabled by the deliberate design of the tunnel. Notably, we observe dual ion release kinetics, highlighting the system's capacity to maintain ion balance in complex environments and adapt to changing conditions. Additionally, we demonstrate selective binding of two different ions-a challenging task for systems lacking structured tunnels.

Identifiers

PMID39610723

DOI10.1021/jacsau.4c00752

PMCPMC11600180

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.