Evidence map›Paper›PMID 39610720›Full record

ArticleJACS Au2024

Design and Evaluation of Pyridinyl Sulfonyl Piperazine LpxH Inhibitors with Potent Antibiotic Activity Against Enterobacterales.

Amanda F Ennis, C Skyler Cochrane, Patrick A Dome, Pyeonghwa Jeong, Jincheng Yu, Hyejin Lee, Carly S Williams, Yang Ha, Weitao Yang, Pei Zhou and 1 more

Abstract read
In one paragraph

Article in JACS Au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Protein-centric mechanisms of typhoidalFrontiers in cellular and infection microbiology · 2026
    Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amanda F EnnisDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.
C Skyler CochraneDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Patrick A DomeDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Pyeonghwa JeongDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Jincheng YuDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.ORCID https://orcid.org/0000-0001-8487-5565
Hyejin LeeDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.
Carly S WilliamsDepartment of Biochemistry, Duke University School of Medicine, Durham, North Carolina 27710, United States.
Yang HaBerkeley Center for Structural Biology, Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, California 94720, United States.ORCID https://orcid.org/0000-0001-5684-8420
Weitao YangDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.ORCID https://orcid.org/0000-0001-5576-2828
Pei ZhouDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.ORCID https://orcid.org/0000-0002-7823-3416
Jiyong HongDepartment of Chemistry, Duke University, Durham, North Carolina 27708, United States.ORCID https://orcid.org/0000-0002-5253-0949

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI PAUL David ADAMS, Gregory L Hura · 2017 to 2026
$28.6M
COMPUTER SIMULATIONS OF ENZYMES AND DNAR01GM061870 · NIGMS · DUKE UNIVERSITY · PI YANG, WEITAO · 2000 to 2022
$5.5M
Pharmacological Sciences Training ProgramT32GM133352 · NIGMS · DUKE UNIVERSITY · PI Cynthia M Kuhn, David M MacAlpine · 2020 to 2026
$3.8M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Discovery and validation of broadly effective LpxH inhibitors as novel therapeutics against multi-drug resistant Gram-negative pathogensR01AI139216 · NIAID · DUKE UNIVERSITY · PI ZHOU, PEI · 2019 to 2022
$1.9M
Biochemistry and Structure of Lipid A EnzymesR01GM115355 · NIGMS · DUKE UNIVERSITY · PI ZHOU, PEI · 2016 to 2019
$1.2M
NIAID NIH HHS R01 AI139216NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM124169NIGMS NIH HHS R01 GM061870NIGMS NIH HHS R01 GM115355NIGMS NIH HHS T32 GM133352NIH HHS S10 OD021527
6 · The paper itself

Abstract

Enterobacterales, a large order of Gram-negative bacteria, including

Identifiers

PMID39610720
PMCPMC11600146

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.