Evidence map›Paper›PMID 39610697›Full record

ArticleFrontiers in cellular neuroscience2024

Neuroinflammation modifies the relationship between stress and perivascular spaces in an elderly population with different levels of cognitive impairment.

Francesca Sibilia, Nasim Sheikh-Bahaei, Wendy J Mack, Giuseppe Barisano, Jeiran Choupan

Abstract read
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In one paragraph

Article in Frontiers in cellular neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Francesca SibiliaLaboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Nasim Sheikh-BahaeiDepartment of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Wendy J MackDepartment of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Giuseppe BarisanoDepartment of Neurosurgery, Stanford University, Stanford, CA, United States.
Jeiran ChoupanLaboratory of Neuro Imaging, USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
Structural and diffusion changes of perivascular space in aging, cognitive decline and Alzheimer's diseaseR01AG070825 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHOUPAN, JEIRAN · 2021 to 2025
$4.1M
Large-scale harmonization and integration of multi-modal ADNI data for the early detection of Alzheimer's disease and related dementiasR01NS128486 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jeiran Choupan, Nasim Sheikh-Bahaei · 2022 to 2026
$4.0M
Development of perivascular space mapping toolset as a diagnostic aid for Alzheimer's diseaseR41AG073024 · NIA · NEUROSCOPE INC. · PI CHOUPAN, JEIRAN · 2021 to 2021
$461k
NIA NIH HHS P30 AG066530NIA NIH HHS R01 AG070825NIA NIH HHS R41 AG073024NIA NIH HHS U01 AG024904NINDS NIH HHS R01 NS128486
6 · The paper itself

Abstract

Background: Perivascular spaces (PVS) are fluid-filled spaces surrounding the brain parenchymal vasculature. Literature suggests that PVS may play a significant role in aging and neurological disorders, including Alzheimer's disease (AD). The aim of this study is to investigate whether the relationship between MRI-visible PVS and stress is influenced by neuroinflammation in an elderly population with different levels of cognitive impairment. Methods: Using brain MRI scans acquired at 1.5 T, PVS were quantified in a cohort of 461 individuals, consisting of cognitively healthy controls ( Results: In the centrum semiovale, higher inflammation levels reduced the relationship of cortisol with PVS. In basal ganglia, higher levels of C-reactive protein reduced the negative relationship of cortisol with PVS. All analyses were accounted for age, sex, body mass index (BMI) and total hippocampal volume. There was a significant interaction effect between cortisol and C-reactive protein on PVS volume fraction in the MCI group. Discussion: These findings suggest an influence of neuroinflammation on the PVS structure in Alzheimer's disease spectrum, and offer insight for better understanding physiological processes of cognitive impairment onset.

Indexed as

Alzheimer’s diseasebiomarkersblood–brain barriercognitive impairmentglymphatic systemneuroinflammationperivascular spacesstress

Identifiers

PMID39610697
PMCPMC11603360

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.