ArticleCureus2024
Investigation of Depression, Anxiety, Sleep Quality, and Fatigue in Thalassemia Major Patients: A Study of the Correlation Between Sleep Quality and Laboratory Findings.
Article in Cureus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Explainable AI framework for improved Thalassemia mental health classification and feature selection.PloS one · 2026Article
- Association of depression and hydroxyurea use with neuropathic pain in hemoglobinopathies.Scientific reports · 2025Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
introductionThalassemia major (TM) experiences a high rate of psychiatric problems, with frequent occurrences of depression and anxiety as well as a high incidence of insomnia. In the present study, we aimed to investigate the severity of depression, anxiety, sleep disorders, sleep quality, and fatigue and explore the relationship between sleep quality and laboratory parameters.
methodsTwenty-eight patients and 37 healthy volunteers were included. Pittsburgh Sleep Quality Index (PSQI), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS), Beck Depression Inventory, Beck Anxiety Inventory, and Fatigue Severity Scale were used.
resultsWe found 46.43% of TM patients had depression, 78.5% had mild anxiety, and 3.57% had severe anxiety. ISI score (p = 0.027), ISI subthreshold insomnia percentage (p = 0.027), PSQI global score (p = 0.002), PSQI insomnia percentage (p = 0.025), PSQI subjective sleep quality (p = 0.008), PSQI sleep latency (p = 0.003), fatigue score (p = 0.026), and chronic fatigue (p = 0.037) percentage were significantly higher in the patients group than in the controls group. Ferritin was positively correlated with PSQI subjective sleep quality (r = 0.478, p = 0.010) and fatigue score (r = 0.427, p = 0.023). Heart involvement in magnetic resonance imaging was positively correlated with ISI score (r = 0.426, p = 0.024) and ISI classification (r = 0.455, p = 0.015). DISCUSSION: Depression and anxiety were significantly higher in TM patients compared to healthy controls. Chronic fatigue and insomnia were more common in TM patients, with subjective sleep quality being impaired and sleep latency prolonged. Furthermore, it was observed that individuals with higher ferritin levels had higher scores of subjective sleep quality and fatigue. Additionally, as cardiac involvement increased, severity of insomnia also increased.
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