Evidence map›Paper›PMID 39610558›Full record

ReviewJournal of diabetes and metabolic disorders2024

Assessing the efficacy of topical formulations in diabetic neuropathy: a narrative review.

Ali Elbeddini, Azasma Tanvir, Orhan Yilmaz, Yusra Rahman, Renata Mongon

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of diabetes and metabolic disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ali ElbeddiniFamily Medicine Department, University of Ottawa, School of Medicine, 600 Peter Morand Crescent Suite 201, Ottawa, ON K1G 5Z3 Canada.ORCID 0000-0002-3339-6203
Azasma TanvirCollege of Medicine, University of Saskatchewan, 107 Wiggins Rd, Saskatoon, SK S7N 5E5 Canada.
Orhan YilmazCollege of Medicine, University of Saskatchewan, 107 Wiggins Rd, Saskatoon, SK S7N 5E5 Canada.
Yusra RahmanFaculty of Health Sciences, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8 Canada.
Renata MongonAnesthesiology Department, State University of Campinas, Campinas, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We conducted a review of topical medications available for alleviation of diabetic neuropathic pain (DNP) and compared their efficacy with oral medications for pain relief. We also explored the feasibility of compounding topical medications. Methods: Searches on PubMed, Medline Ovid, and Embase databases were conducted and findings were presented as a narrative review. Results and discussion: 8% Capsaicin patches and 5% Lidocaine patches had the most evidence. The literature also showed evidence for topical clonidine, gabapentin, and amitriptyline. Conclusion: Topical formulations are a potential substitute to oral medications in patients suffering from DNP. Potential options include 8% Capsaicin patch, 5% Lidocaine patch, Clonidine gel, Topical gabapentin, and an amitriptyline and ketamine combination. A promising area of research that requires further study is the effect of a combination of topicals in alleviated DNP.

Indexed as

Compounding servicesLocalized neuropathic painPatient safety

Identifiers

PMID39610558
PMCPMC11599498

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.