Evidence map›Paper›PMID 39610555›Full record

ArticleJournal of diabetes and metabolic disorders2024

The role of methylation quantification of circulating tumor DNA (ctDNA) as a diagnostic biomarker of Pheochromocytomas (PCCs) and Paragangliomas (PGLs).

Fatemeh Khatami, Leonardo Oliveira Reis, Mehdi Ebrahimi, Shirzad Nasiri, Seyed Mohammad Tavangar, Mahin Ahmadi Pishkuhi, Gita Shafiee, Ramin Heshmat, Seyed Mohammad Kazem Aghamir

Abstract read
In one paragraph

Article in Journal of diabetes and metabolic disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fatemeh KhatamiUrology Research Center, Tehran University of Medical Sciences, Sina Hospital, Hassan Abad Sq., Imam Khomeini Ave, Tehran, Iran.
Leonardo Oliveira ReisUroScience and Department of Surgery (Urology), School of Medical Sciences, University of Campinas, Unicamp, and Pontifical Catholic University of Campinas, PUC-Campinas, Campinas, São Paulo, Brazil.
Mehdi EbrahimiDepartment of Internal Medicine, Faculty of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Shirzad NasiriDepartments of Surgery, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran.
Seyed Mohammad TavangarDepartment of Pathology, Dr. Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mahin Ahmadi PishkuhiUrology Research Center, Tehran University of Medical Sciences, Sina Hospital, Hassan Abad Sq., Imam Khomeini Ave, Tehran, Iran.
Gita ShafieeChronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Ramin HeshmatChronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Seyed Mohammad Kazem AghamirUrology Research Center, Tehran University of Medical Sciences, Sina Hospital, Hassan Abad Sq., Imam Khomeini Ave, Tehran, Iran.ORCID 0000-0003-1611-0362

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Circulating tumor DNAs (ctDNAs) are fragments of malignant tissue DNA that can simply signify the real time genetic change and epigenetic modification of a solid tumor tissue. Pheochromocytomas (PCCs) and Paragangliomas (PGLs) are malinancy of adrenal gland tissue that have the possible diagnosis by ctDNAs. In this study the methylation quanifcation of three target genes Methods: The biological samples include blood and fresh frozen tissue of twelve PCCs/PGLs patients and blood of 12 non tumoral patients as controls were recruited. Semi quantification methylation status of Results: Between six candidate CpG island of Conclusions: Our result shows that the ctDNA hypermethylation of Supplementary Information: The online version contains supplementary material available at 10.1007/s40200-024-01466-8.

Indexed as

ctDNALiquid biopsyMethylationParagangliomaPheochromocytomaRDBP2SDHC1

Identifiers

PMID39610555
PMCPMC11599490

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.