Digital infrared thermography and machine learning for diabetic foot assessment: thermal patterns and classification.

Objectives: Digital infrared thermography is a noninvasive tool used for assessing diseases, including the diabetic foot. This study aims to analyze thermal patterns of the foot sole in patients with type 2 diabetes mellitus using thermography and explore correlations with clinical variables. Additionally, a machine learning approach was developed for classification. Methods: A total of 23 diabetic patients and 27 age- and sex-matched controls were included. Thermograms of the plantar foot surface were acquired and segmented into regions of interest. Mean foot temperature and temperature change index were calculated from predefined regions of interest. Pearson's correlation analysis was conducted for temperature measures, glycated hemoglobin, and body mass index. A two-layered cross-validation model using principal component analysis and support vector machines were employed for classification. Results: Significant positive correlations were found between mean foot temperature and glycated hemoglobin (ρ = 0.44, Conclusions: Thermography combined with machine learning shows potential for assessing diabetic foot complications. Correlations between mean foot temperature and clinical variables suggest foot temperature changes as potential indicators. The machine learning model demonstrates promising accuracy for classification, suitable for screening purposes. Further research is needed to understand underlying mechanisms and establish clinical utility in diagnosing and managing diabetic foot complications.