ArticleJournal of diabetes and metabolic disorders2024
ECG-gated retinal vessel calibre as a novel measure of aberrant pulsatile retinal flow in diabetes mellitus: a cross-sectional study.
Article in Journal of diabetes and metabolic disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Explainable retinal deep learning for cardiovascular risk stratification: a multiple modality analysis framework with vascular-centric interpretability and robustness.BMC medical informatics and decision making · 2026Article
- Carotid Resistance and Pulsatility: Non-Invasive Markers for Diabetes Mellitus-Related Vascular Diseases.Journal of clinical medicine · 2025Article
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4 authors.
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Abstract
Purpose: To evaluate ECG-gated retinal vessel calibre as a novel measure of aberrant pulsatile retinal flow in diabetes mellitus. Methods: A novel mydriatic ECG-gated fundoscope was used to acquire retinal vessel calibre measurements at four cardiac cycle time points from end diastole to early diastole. An inhouse software recorded the exact time when an image was captured to corroborate ECG-synchronisation. Arterial applanation tonometry, an alternative method of assessing aberrant blood flow, was used to measure carotid-femoral pulse wave velocity (cPWV) and augmentation index (AIx). The intraclass correlation (ICC) was used to perform intra- and inter-observer reliability analyses. Two reviewers measured the retinal vessel calibre in single retinal arterioles and venules. A receiver operating characteristic curve determined associations with diabetes mellitus. Results: In this study 119 controls and 120 participants with diabetes mellitus were recruited. Mean peak change in retinal arteriolar calibre from baseline was higher in diabetes mellitus compared with controls (controls: 0.92%, IQR 0.63 vs diabetes mellitus: 2.05%, IQR 1.25, Conclusion: Higher retinal arteriolar pulsatility appears to be more strongly correlated with diabetes mellitus than arterial applanation tonometry.
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