ReviewJournal of diabetes and metabolic disorders2024
The effects of ketogenic diet on metabolic and hormonal parameters in patients with polycystic ovary syndrome: a systematic review and meta-analysis of clinical trials.
Review in Journal of diabetes and metabolic disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Nutrition interventions in women with polycystic ovary syndrome: a systematic review.European journal of nutrition · 2026Pooled it
- Effects of ketogenic diets on polycystic ovary syndrome: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2025Pooled it
- Breaking the metabolic-inflammatory vicious cycle in polycystic ovary syndrome: a comparative review of ketogenic and high-fat diets.Lipids in health and disease · 2025Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: In recent years, using the ketogenic diet (KD) as a potential intervention for polycystic ovary syndrome (PCOS) has gained attention. Therefore, this study aimed to conduct a meta-analysis to determine the effects of KD on sexual hormones, glycemic and lipid parameters in women diagnosed with PCOS. Methods: A comprehensive literature search was performed using online databases such as Medline/PubMed, Scopus, Web of Science (ISI), Embase, and the Cochrane Library and clinical trials were selected based on the inclusion criteria. Data extraction and quality assessment were conducted independently by two investigators using appropriate tools. The effects of a KD on metabolic biomarkers and hormonal parameters were pooled using a random-effects model and were considered as the weighted mean difference (WMD) with corresponding 95% confidence intervals (CIs). Heterogeneity across studies was assessed using Cochran's Q test and the I-square test. Results: Ten studies including 408 women were analyzed in this analysis. Findings showed that KD significantly decreased triglycerides levels (WMD = -44.03 mg/dL; 95% CI, -56.29, -31.76), total cholesterol (-18.95 mg/dL; -29.06, -8.83), and low-density lipoprotein cholesterol (LDL) (-18.11 mg/dL; -29.56, -6.67) compared to the control groups. KD also led to a notable reduction in fasting glucose (-10.30 mg/dL; -14.10, -6.50) and HOMA-IR (-1.93; -3.66, -0.19). Also, this diet led to a significant decrease in luteinizing hormone (LH) levels (-3.75 mIU/mL; -3.84, -3.65) and total testosterone levels (-7.71 ng/dL); -12.08, -3.35), while follicle-stimulating hormone (FSH) increased (0.43 mIU/mL; 0.29, 0.57). Conclusion: The KD demonstrated promising outcomes in improving metabolic and hormonal parameters in women diagnosed with PCOS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.