Evidence map›Paper›PMID 39610416›Full record

ArticleJPGN reports2024

Extrahepatic biliary atresia and normal-range serum gamma-glutamyltranspeptidase activity: A case report.

Benno Kohlmaier, Heidelis Tichy, Jasmin Blatterer, Holger Till, Axel Schlagenhauf, A S Knisely

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JPGN reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Benno KohlmaierDepartment of Pediatrics and Adolescent Medicine, Division of General Pediatrics Medical University of Graz Graz Austria.ORCID https://orcid.org/0000-0003-0685-689X
Heidelis TichyDiagnostic and Research Institute of Human Genetics Medical University of Graz Graz Austria.
Jasmin BlattererDiagnostic and Research Institute of Human Genetics Medical University of Graz Graz Austria.
Holger TillDepartment of Paediatric and Adolescent Surgery Medical University of Graz Graz Austria.
Axel SchlagenhaufDepartment of Pediatrics and Adolescent Medicine, Division of General Pediatrics Medical University of Graz Graz Austria.
A S KniselyDiagnostic and Research Institute of Pathology Medical University of Graz Graz Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An infant with biliary atresia had normal-range ('low') serum gamma-glutamyltranspeptidase (GGT) activity, exceptional because GGT generally is elevated in biliary atresia. Mechanisms underlying low-GGT cholestasis in biliary atresia are not defined, but the phenomenon is associated with worse clinical outcome. Testing in our patient revealed no variants in genes mutated in several disorders also associated with poor prognosis and with low-GGT cholestasis; indeed, at age 14 months she has stable disease with unremarkable biomarker values. Nonetheless, we recommend extended investigations in such patients, including genetic testing, to detect coexistent disorders and to expand understanding of GGT in biliary atresia.

Indexed as

gamma‐glutamyl transferaselow GGTnormal GGT

Identifiers

PMID39610416
PMCPMC11600354

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.