Evidence map›Paper›PMID 39610401›Full record

ArticleOptica2024

High-speed two-photon microscopy with adaptive line-excitation.

Yunyang Li, Shu Guo, Ben Mattison, Junjie Hu, Kwun Nok Mimi Man, Weijian Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Optica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Color-neutral and reversible tissue transparency enables longitudinal deep-tissue imaging in live mice.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yunyang LiDepartment of Electrical and Computer Engineering, University of California, Davis, California 95616, USA.ORCID https://orcid.org/0000-0002-4847-4761
Shu GuoDepartment of Electrical and Computer Engineering, University of California, Davis, California 95616, USA.ORCID https://orcid.org/0009-0004-8171-7907
Ben MattisonDepartment of Biomedical Engineering, University of California, Davis, California 95616, USA.ORCID https://orcid.org/0009-0005-9222-8129
Junjie HuDepartment of Electrical and Computer Engineering, University of California, Davis, California 95616, USA.
Kwun Nok Mimi ManDepartment of Biochemistry and Molecular Medicine, University of California, Davis, California 95616, USA.
Weijian YangDepartment of Electrical and Computer Engineering, University of California, Davis, California 95616, USA.ORCID https://orcid.org/0000-0003-0941-3496

Funding

Large-field-of-view high-throughput two-photon endoscope to image neuronal activityR01NS118289 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI YANG, WEIJIAN · 2020 to 2020
$1.4M
NINDS NIH HHS R01 NS118289
6 · The paper itself

Abstract

We present a two-photon fluorescence microscope designed for high-speed imaging of neural activity at cellular resolution. Our microscope uses an adaptive sampling scheme with line illumination. Instead of building images pixel by pixel via scanning a diffraction-limited spot across the sample, our scheme only illuminates the regions of interest (i.e., neuronal cell bodies) and samples a large area of them in a single measurement. Such a scheme significantly increases the imaging speed and reduces the overall laser power on the brain tissue. Using this approach, we performed high-speed imaging of the neuronal activity in mouse cortex

Identifiers

PMID39610401
PMCPMC11601119

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.