Evidence map›Paper›PMID 39610287›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Meaning in life and neurobiomarkers of brain health in the UK Biobank.

Angelina Sutin, Martina Luchetti, Yannick Stephan, Antonio Terracciano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Purpose in life and blood-based biomarkers of brain health.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Angelina SutinFlorida State University College of Medicine, Tallahassee, FL, USA.ORCID 0000-0002-1824-8974
Martina LuchettiFlorida State University College of Medicine, Tallahassee, FL, USA.ORCID 0000-0002-7370-8443
Yannick StephanUniversity of Montpellier, Montpellier, France.
Antonio TerraccianoFlorida State University College of Medicine, Tallahassee, FL, USA.

Funding

Purpose in life: Mechanisms to support healthier cognitive aging and reduce risk of Alzheimer's diseaseR01AG074573 · NIA · FLORIDA STATE UNIVERSITY · PI SUTIN, ANGELINA R · 2021 to 2025
$3.5M
NIA NIH HHS R01 AG074573
6 · The paper itself

Abstract

This study examines meaning in life and four neurobiomarkers implicated in dementia risk: amyloid-β 42 to 40 ratio, phosphorylated tau-181, neurofilament light, and glial fibrillary acidic protein. Adults without dementia (

Indexed as

BrainAgedAged, 80 and overAmyloid beta-PeptidesBiological Specimen BanksBiomarkersFemaleGlial Fibrillary Acidic ProteinHumansMaleMiddle AgedNeurofilament ProteinsPeptide Fragmentstau ProteinsUK BiobankUnited KingdomAmyloid beta-Peptidesamyloid beta-protein (1-40)amyloid beta-protein (1-42)BiomarkersGlial Fibrillary Acidic Proteinneurofilament protein LNeurofilament ProteinsPeptide Fragmentstau ProteinsAlzheimer's diseasedementiameaning in lifeneurodegenerationneuroinflammationneuronal injurypurpose in life

Identifiers

PMID39610287
PMCPMC11984414

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.