Evidence map›Paper›PMID 39610015›Full record

ReviewWound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Photobiomodulation studies on diabetic wound healing: An insight into the inflammatory pathway in diabetic wound healing.

Tintswalo N Mgwenya, Heidi Abrahamse, Nicolette N Houreld

Abstract readReview
In one paragraph

Review in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  16. Photobiomodulation therapy.JADA foundational science · 2025
    Review
  17. Photobiomodulation studies on diabetic wound healing: An insight into the inflammatory pathway in diabetic wound healing.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Tintswalo N MgwenyaLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, Johannesburg, Gauteng, South Africa.
Heidi AbrahamseLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, Johannesburg, Gauteng, South Africa.
Nicolette N HoureldLaser Research Centre, Faculty of Health Sciences, University of Johannesburg, Johannesburg, Gauteng, South Africa.ORCID 0000-0002-1515-8260

Funding

African Laser Centre (ALC) HLHA24X task ALC-R007Council for Scientific and Industrial Research (CSIR)-National Laser Centre (NLC), Laser Rental Pool ProgrammeNational Research Foundation (NRF) of South Africa Competitive Programme for Rated Researchers 1293270South African Research Chairs Initiative of the Department of Science and Technology (DST) and National Research Foundation (NRF) of South Africa 98337University of Johannesburg (URC)
6 · The paper itself

Abstract

Diabetes mellitus remains a global challenge to public health as it results in non-healing chronic ulcers of the lower limb. These wounds are challenging to heal, and despite the different treatments available to improve healing, there is still a high rate of failure and relapse, often necessitating amputation. Chronic diabetic ulcers do not follow an orderly progression through the wound healing process and are associated with a persistent inflammatory state characterised by the accumulation of pro-inflammatory macrophages, cytokines and proteases. Photobiomodulation has been successfully utilised in diabetic wound healing and involves illuminating wounds at specific wavelengths using predominantly light-emitting diodes or lasers. Photobiomodulation induces wound healing through diminishing inflammation and oxidative stress, among others. Research into the application of photobiomodulation for wound healing is current and ongoing and has drawn the attention of many researchers in the healthcare sector. This review focuses on the inflammatory pathway in diabetic wound healing and the influence photobiomodulation has on this pathway using different wavelengths.

Indexed as

InflammationLow-Level Light TherapyWound HealingCytokinesDiabetic FootHumansOxidative StressCytokinesdiabetesinflammationlaser therapyphotobiomodulationwound healing

Identifiers

PMID39610015
PMCPMC11628774

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.