Evidence map›Paper›PMID 39609812›Full record

ArticleBMC biology2024

Tripartite interactions of PKA catalytic subunit and C-terminal domains of cardiac Ca

Shimrit Oz, Tal Keren-Raifman, Tom Sharon, Suraj Subramaniam, Tamara Pallien, Moshe Katz, Vladimir Tsemakhovich, Anastasiia Sholokh, Baraa Watad, Debi Ranjan Tripathy and 13 more

Abstract read
In one paragraph

Article in BMC biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Shimrit OzSchool of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel.
Tal Keren-RaifmanSchool of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel.
Tom SharonSchool of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel.
Suraj SubramaniamSchool of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997601, Israel.
Tamara PallienMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Moshe KatzSchool of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel.
Vladimir TsemakhovichSchool of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel.
Anastasiia SholokhMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Baraa WatadSchool of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel.
Debi Ranjan TripathySchool of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel.
Giorgia SassonSchool of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997601, Israel.
Orna Chomsky-HechtSchool of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997601, Israel.
Leonid VysochekHeart Center, Sheba Medical Center, Ramat Gan, 5262000, Israel.
Maike Schulz-ChristianMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Claudia Fecher-TrostExperimentelle Und Klinische Pharmakologie & Toxikologie, Universität Des Saarlandes, Homburg, 66421, Germany.
Kerstin ZühlkeMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Daniela BertinettiDepartment of Biochemistry, University of Kassel, Heinrich-Plett-Str. 40, Kassel, 34132, Germany.
Friedrich W HerbergDepartment of Biochemistry, University of Kassel, Heinrich-Plett-Str. 40, Kassel, 34132, Germany.
Veit FlockerziExperimentelle Und Klinische Pharmakologie & Toxikologie, Universität Des Saarlandes, Homburg, 66421, Germany.
Joel A HirschSchool of Neurobiology, Biochemistry and Biophysics, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, 6997601, Israel.
Enno KlussmannMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.
Sharon WeissSchool of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel. lahavsha@tauex.tau.ac.il.
Nathan DascalSchool of Medicine, Faculty of Medical and Health Sciences, Tel Aviv University, 6997601, Tel Aviv, Israel. dascaln@tauex.tau.ac.il.ORCID 0000-0002-5397-4146

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe β-adrenergic augmentation of cardiac contraction, by increasing the conductivity of L-type voltage-gated Ca

resultsWe show that PKAC interacts with Ca

conclusionsWe discover direct interactions between PKAC and two domains in Ca

Indexed as

Calcium Channels, L-TypeCyclic AMP-Dependent Protein KinasesReceptors, Adrenergic, betaAnimalsCatalytic DomainHumansMiceMyocytes, CardiacProtein DomainsCalcium Channels, L-TypeCyclic AMP-Dependent Protein KinasesReceptors, Adrenergic, betaAdrenergic regulationCalcium channelCardiacHeterologous expressionProtein kinase A (PKA)Protein‐protein interaction

Identifiers

PMID39609812
PMCPMC11603854

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.