ArticleBMC medicine2024
Exploring the link between dietary patterns and gastric adenocarcinoma in Brazil: a mediation analysis.
Article in BMC medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Processed meat intake and gastric adenocarcinoma risk among adults in Central-West Brazil: a case-control study.BMC nutrition · 2026Article
- Plant-Based Diet Quality and Gastric Cancer Risk: A Case-Control Study in High-Risk Regions of Fujian Province, China.Food science & nutrition · 2026Article
- Impact of high sodium intake on stomach cancer burden in China: A comprehensive analysis from 1990 to 2021.PloS one · 2026Article
- The global cancer crisis: a review of growing burden, deepening inequality and initiatives for prevention and early detection.Ecancermedicalscience · 2026Review
- Early-onset gastric cancer global burden profile, trends, and contributors.Cancer biology & medicine · 2025Article
- Time trends in stomach cancer mortality across the BRICS: an age-period-cohort analysis for the GBD 2021.Frontiers in public health · 2025Article
- Mala flavor preference increases risk of excessive gestational weight gain mediated by high-carbohydrate dietary patterns in Chongqing, China: an ambispective cohort study.Frontiers in nutrition · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe causal pathway between different dietary patterns (DPs) and gastric adenocarcinoma (GA) remains largely unexplored. The study aimed to identify DPs and evaluate how selected nutrients mediate the relationship between DPs and GA.
methodsThis multicenter case-control study in Brazil involved 1751 participants (600 cases, 377 endoscopic controls, and 774 hospital controls). DPs were identified through exploratory factor analysis. A counterfactual-based mediation analysis was performed to decompose the total effect of DPs on GA into direct and indirect effects mediated by saturated fatty acids, added sugars, total fiber, and sodium intakes. Effects were expressed as ORs and 95% CIs.
resultsTwo DPs were identified-"unhealthy dietary pattern" (UDP) and "healthy dietary pattern" (HDP), which were associated with an increased and decreased risk of GA, respectively. Added sugars partly mediated the association between UDP and GA (percentage mediated between 7.3 and 21.7%), while sodium intake mediated most of the association between HDP and GA (percentage mediated between 52.4 and 100%). No significant mediating effects were detected for saturated fatty acids and total fiber.
conclusionsThis study contributes innovative insights into the DPs-GA relationships, highlighting the significant mediating roles of sodium and added sugars, offering valuable information for preventive strategies and public health interventions targeting GA.
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