Evidence map›Paper›PMID 39609809›Full record

ArticleJournal of nanobiotechnology2024

Accurate HER2 determination in breast cancer: a prominent COF-immobilized enzyme-enhanced electrochemical aptasensor employing 4-acetamidophenol as an efficient mediator.

Yue Zhang, Shuyi Chen, Jie Ma, Xiaobin Zhou, Xinchen Sun, Chenglin Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yue ZhangClinical Medical Laboratory Center, Gaogang Branch, Taizhou School of Clinical Medicine, Nanjing Medical University, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, China. yue_zhang@aa.seu.edu.cn.
Shuyi ChenClinical Medical Laboratory Center, Gaogang Branch, Taizhou School of Clinical Medicine, Nanjing Medical University, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, China.
Jie MaClinical Laboratory Department, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Xiaobin ZhouClinical Medical Laboratory Center, Gaogang Branch, Taizhou School of Clinical Medicine, Nanjing Medical University, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, China.
Xinchen SunClinical Medical Laboratory Center, Gaogang Branch, Taizhou School of Clinical Medicine, Nanjing Medical University, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, China.
Chenglin ZhouClinical Medical Laboratory Center, Gaogang Branch, Taizhou School of Clinical Medicine, Nanjing Medical University, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, 225300, China. 18762340015@njmu.edu.cn.

Funding

The High-level Innovation and Entrepreneurship Talent Introduction Plan of Jiangsu Province JSSCBS20211599the NSFC Cultivation Project of Nanjing Medical University TZKY20220103
6 · The paper itself

Abstract

An effective strategy for enzyme-enhanced electrochemical detection of human epidermal growth factor receptor 2 (HER2) is proposed for breast cancer diagnosis. This strategy utilizes a three-dimensional mesoporous covalent organic framework (COF), immobilized horseradish peroxidase (HRP), and a novel redox mediator, 4-acetamidophenol (APAP). The mesoporous structure, with encapsulation effect, and good biocompatibility of COF, makes the functionalized COF an efficient carrier for HRP immobilization (HRP-Ab-AuNPs@COF). It demonstrates superior catalytic activity, stability, and electrochemical performance compared to free HRP, thus making it an ideal probe for simultaneous target recognition and signal amplification. APAP is screened from four candidate phenolic compounds based on its high formal potential (0.32 V vs. Ag/AgCl), rapid electron transfer activity (k

Indexed as

Biosensing TechniquesBreast NeoplasmsElectrochemical TechniquesEnzymes, ImmobilizedErb-b2 Receptor Tyrosine KinasesGoldHorseradish PeroxidaseMetal-Organic FrameworksAptamers, NucleotideFemaleHumansLimit of DetectionMetal NanoparticlesNanotubes, CarbonAptamers, NucleotideEnzymes, ImmobilizedERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesGoldHorseradish PeroxidaseMetal-Organic FrameworksNanotubes, Carbon4-acetamidophenolBreast cancerCovalent organic frameworkElectrochemical aptasensingImmobilized enzyme

Identifiers

PMID39609809
PMCPMC11605949

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.