Evidence map›Paper›PMID 39609781›Full record

ArticleBMC pulmonary medicine2024

Ciprofol prevents ferroptosis in LPS induced acute lung injury by activating the Nrf2 signaling pathway.

Qin Zhao, Chang Kong, Xiuyun Wu, Yong Ling, Jia Shi, Shaona Li, Youzhuang Zhu, Jianbo Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qin Zhao *Tianjin NanKai Hospital, Tianjin Medical University, Tianjin, China.
Chang Kong *Tianjin NanKai Hospital, Tianjin Medical University, Tianjin, China.
Xiuyun Wu *Department of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yong LingDepartment of Pharmacy, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Jia ShiTianjin NanKai Hospital, Tianjin Medical University, Tianjin, China.
Shaona LiDepartment of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Youzhuang ZhuDepartment of Anesthesiology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Jianbo YuTianjin NanKai Hospital, Tianjin Medical University, Tianjin, China. 30717008@nankai.edu.cn.

Funding

the Youth Science Foundation of Affiliated Hospital of Qingdao University QDFYQN2023230
6 · The paper itself

Abstract

backgroundPatients who suffered from sepsis-induced acute lung injury (ALI) always need sedation for mechanical ventilation in intensive care unit (ICU). Ciprofol(Cip), a novel intravenous anesthetic, was revealed to have anti-inflammatory and antioxidative properties. Ferroptosis, categorized as a type of newly non-apoptotic cell death, participates in the development of lung injury. This study aimed to identify the effect of ciprofol on sepsis-induced ALI and to determine whether ferroptosis is involved. METHODS AND

resultsTo create ALI models, MLE12 alveolar epithelial. Cells and lipopolysaccharide (LPS)-stimulated C57BL/6J mice were used. Our results displyed that Cip reduced lung injury and ferroptosis. In the LPS-induced sepsis mice model, Cip pretreatment partially reduced respiratory system damage, as evaluated by HE, TUNEL and inflammatory factors. By raising GSH levels, ciprofol activated the Nrf2 antioxidative pathway, blocked ferroptosis, increased ferroptosis-related protein (GPX4 and SLC7A11) expressions, and reduced Fe

conclusionOur study demonstrated that Cip may prevent septic lung injury by suppressing ferroptosis through the Nrf2 pathway.

Indexed as

Acute Lung InjuryDisease Models, AnimalFerroptosisLipopolysaccharidesMice, Inbred C57BLNF-E2-Related Factor 2SepsisSignal TransductionAmino Acid Transport System y+AnimalsCyclopropanesMaleMiceMice, KnockoutPhospholipid Hydroperoxide Glutathione Peroxidase(2-(1R)-1-cyclopropyl)ethyl-6-isopropyl-phenolAmino Acid Transport System y+Cyclopropanesglutathione peroxidase 4, mouseLipopolysaccharidesNfe2l2 protein, mouseNF-E2-Related Factor 2Phospholipid Hydroperoxide Glutathione PeroxidaseSlc7a11 protein, mouseAcute lung injuryCiprofol(Cip)FerroptosisGlutathione peroxidase 4 (GPX4)Nuclear factor erythroid-2 related factor 2 (Nrf2)

Identifiers

PMID39609781
PMCPMC11606060

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.