Evidence map›Paper›PMID 39609706›Full record

ArticleDiabetology & metabolic syndrome2024

Differential effects of leptin on energy metabolism in murine cell models of metastatic triple negative breast cancer.

Chaehyun Yum, Chaylen Andolino, Marjorie Anne Layosa, Michael Coleman, Stephen D Hursting, Dorothy Teegarden

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetology & metabolic syndrome, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chaehyun YumDepartment of Nutrition Science, Interdepartmental Nutrition Program, Purdue University, West Lafayette, IN, 47907, USA.
Chaylen AndolinoDepartment of Nutrition Science, Interdepartmental Nutrition Program, Purdue University, West Lafayette, IN, 47907, USA.
Marjorie Anne LayosaDepartment of Nutrition Science, Interdepartmental Nutrition Program, Purdue University, West Lafayette, IN, 47907, USA.
Michael ColemanDepartment of Nutrition, University of North Carolina, Chapel Hill, NC, 27516, USA.
Stephen D HurstingDepartment of Nutrition, University of North Carolina, Chapel Hill, NC, 27516, USA.
Dorothy TeegardenDepartment of Nutrition Science, Interdepartmental Nutrition Program, Purdue University, West Lafayette, IN, 47907, USA. teegarden@purdue.edu.

Funding

Obesity, Metabolism and Breast Cancer MetastasisR01CA232589 · NCI · PURDUE UNIVERSITY · PI HURSTING, STEPHEN D, TEEGARDEN, DOROTHY · 2019 to 2023
$2.6M
Impact of hypoxia on lipid metabolism in obesity-driven breast cancer progressionR01CA271597 · NCI · PURDUE UNIVERSITY · PI Stephen D Hursting, Dorothy Teegarden · 2023 to 2026
$2.5M
NCI NIH HHS R01 CA232589NCI NIH HHS R01 CA271597NIH HHS R01CA232589U.S. Department of Agriculture Hatch Funds
6 · The paper itself

Abstract

backgroundLeptin, an energy balance regulator secreted by adipocytes, increases metastatic potential of breast cancer cells. The impact on cancer cell metabolism remains unclear given that most studies of leptin and breast cancer cell metabolism utilize supraphysiological glucose concentrations.

methodsUsing two murine models of metastatic triple-negative breast cancer (TNBC) differing in genetic alterations (4T1: p53 and Pik3ca mutations; metM-Wnt

resultsOur results showed that leptin treatment, compared with vehicle, increased cell migration in each cell line, with decreased leptin receptor (Ob-R) mRNA expression in 4T1, but not metM-Wnt

conclusionTaken together, these results demonstrate that at physiological glucose concentrations, leptin increases migration of 4T1 and metM-Wnt

Indexed as

Breast cancerFatty acidGlucoseLeptin

Identifiers

PMID39609706
PMCPMC11603625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.