Evidence map›Paper›PMID 39609652›Full record

ArticleNature structural & molecular biology2025

Closed and open structures of the eukaryotic magnesium channel Mrs2 reveal the auto-ligand-gating regulation mechanism.

Ping Li, Shiyan Liu, Johan Wallerstein, Rhiza Lyne E Villones, Peng Huang, Karin Lindkvist-Petersson, Gabriele Meloni, Kefeng Lu, Kristine Steen Jensen, Sara I Liin and 1 more

Abstract read
In one paragraph

Article in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ping LiDepartment of Experimental Medical Science, Lund University, Lund, Sweden. ping.li@med.lu.se.ORCID http://orcid.org/0000-0002-7364-3301
Shiyan LiuDepartment of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Johan WallersteinDivision of Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, Lund, Sweden.
Rhiza Lyne E VillonesDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.
Peng HuangDepartment of Experimental Medical Science, Lund University, Lund, Sweden.
Karin Lindkvist-PeterssonDepartment of Experimental Medical Science, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0002-5209-3160
Gabriele MeloniDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX, USA.ORCID http://orcid.org/0000-0003-4976-1401
Kefeng LuDepartment of Neurosurgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0001-8200-9380
Kristine Steen JensenDivision of Biophysical Chemistry, Center for Molecular Protein Science, Department of Chemistry, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-9174-8361
Sara I LiinDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.ORCID http://orcid.org/0000-0001-8493-0114
Pontus GourdonDepartment of Experimental Medical Science, Lund University, Lund, Sweden. pontus.gourdon@med.lu.se.ORCID http://orcid.org/0000-0002-8631-3539

Funding

Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteinsR35GM128704 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Gabriele Meloni · 2018 to 2026
$3.5M
NIGMS NIH HHS R35 GM128704
6 · The paper itself

Abstract

The CorA/Mrs2 family of pentameric proteins are cardinal for the influx of Mg

Indexed as

Cation Transport ProteinsIon Channel GatingMagnesiumMitochondrial ProteinsSaccharomyces cerevisiae ProteinsBinding SitesCryoelectron MicroscopyLigandsMitochondriaModels, MolecularProtein ConformationSaccharomyces cerevisiaeCation Transport ProteinsLigandsMagnesiumMitochondrial ProteinsSaccharomyces cerevisiae Proteins

Identifiers

PMID39609652
PMCPMC11919701

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.