Evidence map›Paper›PMID 39609651›Full record

ArticleNature structural & molecular biology2025

Structure and function of the human mitochondrial MRS2 channel.

Zhihui He, Yung-Chi Tu, Chen-Wei Tsai, Jonathan Mount, Jingying Zhang, Ming-Feng Tsai, Peng Yuan

Abstract read
In one paragraph

Article in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. MRS2 missense variation at Asp216 abrogates inhibitory MgProtein science : a publication of the Protein Society · 2024
    Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Zhihui He *Department of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0003-4184-8377
Yung-Chi Tu *Department of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID http://orcid.org/0009-0007-5074-4883
Chen-Wei TsaiDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Jonathan MountDepartment of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.
Jingying ZhangDepartment of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA.
Ming-Feng TsaiDepartment of Physiology and Biophysics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. vmf6uw@virginia.edu.ORCID http://orcid.org/0000-0003-4277-1885
Peng YuanDepartment of Cell Biology and Physiology, Washington University School of Medicine, Saint Louis, MO, USA. peng.yuan@mssm.edu.ORCID http://orcid.org/0000-0002-5660-225X

Funding

Molecular Mechanisms of Copper TransportR01NS109307 · NINDS · WASHINGTON UNIVERSITY · PI YUAN, PENG · 2018 to 2022
$1.7M
STRUCTURE AND MECHANISM OF A POLYMODAL TRP ION CHANNELR01NS099341 · NINDS · WASHINGTON UNIVERSITY · PI YUAN, PENG · 2017 to 2021
$1.7M
Molecular mechanisms of the mitochondrial calcium transport systemR35GM151958 · NIGMS · UNIVERSITY OF VIRGINIA · PI Ming-Feng Tsai · 2024 to 2026
$1.6M
Structural Mechanism for Gating of Mechanosensitive ChannelsR01GM143440 · NIGMS · WASHINGTON UNIVERSITY · PI YUAN, PENG · 2022 to 2025
$1.6M
Molecular Physiology of Mitochondrial Calcium TransportersR01GM144485 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI TSAI, MING-FENG · 2021 to 2023
$968k
NIGMS NIH HHS R01 GM143440NIGMS NIH HHS R01 GM144485NIGMS NIH HHS R35 GM151958NINDS NIH HHS R01 NS099341NINDS NIH HHS R01 NS109307
6 · The paper itself

Abstract

The human mitochondrial RNA splicing 2 protein (MRS2) has been implicated in Mg

Indexed as

Ion ChannelsMitochondriaMitochondrial ProteinsCalciumCryoelectron MicroscopyHumansMagnesiumModels, MolecularCalciumIon ChannelsMagnesiumMitochondrial Proteins

Identifiers

PMID39609651
PMCPMC11922672

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.