ReviewPediatric research2025
If things were simple, word would have gotten around. Can complexity science help us improve pediatric research?
Review in Pediatric research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Embracing complexity in transfusion research.Vox sanguinis · 2026Review
- Complexity and risk factor research in mental disorders: better think twice.Frontiers in psychiatry · 2026Article
- AI and Computational Methods for Modelling, Simulations and Optimizing of Advanced Systems: Innovations in Complexity.Materials (Basel, Switzerland) · 2025Article
- Exploring Complexity in Out-of-Hospital Clinical Supervision Using Rich Pictures.Perspectives on medical education · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complexity science is a discipline which explores how complex systems behave and how we interact with them. Though it is widely implemented outside medicine, particularly in the sciences involving human behavior, but also in the natural sciences such as physics and biology, there are only a few applications within medical research. We propose that complexity science can provide new and helpful perspectives on complex pediatric medical problems. It can help us better understand complex systems and develop ways to cope with their inherent unpredictabilities. In this article, we provide a brief introduction of complexity science, explore why many medical problems can be considered 'complex', and discuss how we can apply this perspective to pediatric research. IMPACT: Current methods in pediatric research often focus on single mechanisms or interventions instead of systems, and tend to simplify complexity. This may not be appropriate. Complexity science provides a framework and a toolbox to better address complex problems. This review provides a starting point for the application of complexity science in pediatric research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.