Evidence map›Paper›PMID 39609584›Full record

ArticleScientific reports2024

Staphylococcus aureus enterotoxin sensitization is associated with declined capsaicin cough sensitivity in chronic obstructive pulmonary disease.

Yoshihiro Kanemitsu, Kensuke Fukumitsu, Ryota Kurokawa, Taisuke Akamatsu, Satoshi Fukuda, Yutaka Ito, Yuki Amakusa, Tatsuro Suzuki, Keima Ito, Yuta Mori and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yoshihiro KanemitsuDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan. kaney32@med.nagoya-cu.ac.jp.
Kensuke FukumitsuDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.
Ryota KurokawaDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.
Taisuke AkamatsuDepartment of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
Satoshi FukudaDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.
Yutaka ItoDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.
Yuki AmakusaDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.
Tatsuro SuzukiDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.
Keima ItoDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.
Yuta MoriDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.
Takehiro UemuraDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.
Tomoko TajiriDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.
Hirotsugu OhkuboDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.
Toshihiro ShiraiDepartment of Respiratory Medicine, Shizuoka General Hospital, Shizuoka, Japan.
Akio NiimiDepartment of Respiratory Medicine, Allergy, and Clinical Immunology, Graduate school of Medical Sciences, Nagoya City University, Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, Aichi, Japan.

Funding

a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government 20K17220
6 · The paper itself

Abstract

Sensitization to Staphylococcus aureus (S. aureus) enterotoxins (SEs) A (SEA) and B (SEB) is associated with the pathogenesis of several chronic airway diseases, including asthma and chronic rhinosinusitis, but its role in chronic obstructive pulmonary disease (COPD) remains unclear. This cohort study aimed to investigate the impact of sensitization to SEs on total IgE levels, and capsaicin cough reflex sensitivity (C-CS) in COPD. This study prospectively enrolled 68 patients with COPD from the outpatient department at Nagoya City University Hospital and Shizuoka General Hospital, Japan, from June 2018 to January 2020 for posthoc analysis. Patient characteristics and biomarkers, including total IgE, and C-CS, were collected. We additionally measured and serum SEA-IgE and SEB-IgE levels for this analysis. Total IgE and SEs-IgE levels in individuals with COPD were compared to those of 20 healthy individuals. The correlation between C-CS and IgE levels was evaluated using Pearson's correlation coefficient. Multivariate analyses were used to adjust the impact on SE sensitization in total IgE levels and C-CS. The prevalence of SEs sensitization was higher in patients with COPD (23.5%, N = 16) than in healthy individuals (0%, N = 0) at a cut-off value of 0.35 UA/mL or more (p = 0.018). There was a negative correlation between total serum SEB-IgE levels and declined C-CS values. Multivariate analysis showed that SEs sensitization was associated with increased total IgE levels, and declined C-CS values. This study indicated that SEs sensitization was associated with increased IgE levels and decreased C-CS in COPD. This study was approved by the ethics committee of Nagoya City University (60-18-0012) and registered in the UMIN Clinical Trials Registry (Registry ID UMIN000032497).

Indexed as

CapsaicinCoughEnterotoxinsImmunoglobulin EPulmonary Disease, Chronic ObstructiveStaphylococcus aureusAgedFemaleHumansJapanMaleMiddle AgedProspective StudiesCapsaicinenterotoxin A, Staphylococcalenterotoxin B, staphylococcalEnterotoxinsImmunoglobulin ECapsaicin cough reflex sensitivityChronic obstructive pulmonary diseaseIgEStaphylococcus aureusStaphylococcus aureus enterotoxins

Identifiers

PMID39609584
PMCPMC11604919

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.