Evidence map›Paper›PMID 39609345›Full record

ArticleEJNMMI research2024

Impact of cognitive impairment on heart failure prognosis: insights into central nervous system mechanism.

Zhiyong Shi, Mingkai Yun, Binbin Nie, Enjun Zhu, Wei Fu, Baoci Shan, Sijin Li, Xiaoli Zhang, Xiang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiyong Shi *Department of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Mingkai Yun *Department of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Binbin NieDivision of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
Enjun ZhuDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Wei FuDepartment of Cardiac Surgery, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Baoci ShanDivision of Nuclear Technology and Applications, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
Sijin LiDepartment of Nuclear Medicine, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Xiaoli ZhangDepartment of Nuclear Medicine, Molecular Imaging Lab, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. xlzhang68@126.com.ORCID http://orcid.org/0000-0002-0770-5594
Xiang LiDivision of Nuclear Medicine, Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.

Funding

Advanced Research Foundation of Capital Medical University PYZ21121Beijing Municipal Administration of Hospitals ZYLX202110National Natural Science Foundation of China 81871377National Natural Science Foundation of China 82027804National Natural Science Foundation of China 82171994
6 · The paper itself

Abstract

backgroundEpidemiological studies have indicated that patients with heart failure (HF) who experience cognitive impairment (CI) have a poor prognosis. While poor self-management and compliance are suggested as contributing factors, they do not fully explain the underlying mechanisms of high risk of cardiac events in HF patients with CI. Given the interconnectedness of CI and the autonomic nervous system (ANS), both regulated by the central nervous system, this study investigated the relationship among cognitive function, metabolism in ANS-related brain regions, and major arrhythmic events (MAEs) in patients with HF with reduced ejection fraction (HFrEF).

resultsWe retrospectively enrolled 72 patients with HFrEF who underwent gated myocardial perfusion imaging, heart and brain

conclusionANS dysfunction, exacerbated by reduced metabolism in ANS-related brain regions and CAN connectivity, contributed to an increased risk of MAEs in HFrEF patients with CI.

Indexed as

18F-FDG PETBrain–heart axisBrain networkCognitive impairmentHeart failureQTc interval

Identifiers

PMID39609345
PMCPMC11604885

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.