ArticleEuropean journal of ageing2024
Lifestyle factors and incident multimorbidity related to chronic disease: a population-based cohort study.
Article in European journal of ageing, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Nurse-Led Interventions to Improve Health, Adherence, and Functional Outcomes in Adults and Older Adults With Multimorbidity: A Systematic Review of Randomized and Quasiexperimental Studies.Journal of nursing management · 2025Pooled it
- Stress biology and metabolic ageing in older adults during prolonged crises: Ukraine as an example.Biogerontology · 2026Review
- Classification and Severity Assessment of Obesity in Clinical Risk Prediction of Multimorbidity Trajectories.Clinical obesity · 2026Article
- Article
- Patterns of multimorbidity and their association with edentulism: the moderating role of health literacy in the Lifelines Cohort.European journal of public health · 2026Article
- Effect of Chronic Noncommunicable Diseases Multimorbidity on Functional Disability in Older Adults in Ireland: Evidence From the 2019 Irish Health Survey.Chronic diseases and translational medicine · 2026Article
- Body roundness index modified the association between sleep changes and multimorbidity in middle-aged and older adults: a nationwide cohort study.Journal of health, population, and nutrition · 2026Article
- Proteomics signature of moderate-to-vigorous physical activity and risk of multimorbidity of cancer and cardiometabolic diseases.Communications medicine · 2026Article
- Bridging Population Patterns and Individual Prediction: Framework for Prospective Multimorbidity Study.JMIR medical informatics · 2026Article
- Social, psychosocial, and lifestyle determinants of diabetes and prediabetes in US adults before and after COVID-19: a cross-sectional NHANES analysis.Diabetology & metabolic syndrome · 2026Article
- Unmasking hidden pathways: how household air pollution and lifestyle are associated with quality of life in Yunnan outpatients.Frontiers in public health · 2026Article
- The Digital Amplifier in Medical Insurance: How Chinese Provincial Pooling Policy Optimizes Chronic Disease Management.Healthcare (Basel, Switzerland) · 2025Article
- Article
- Sociodemographic inequalities in multimorbidity and lifestyle risk factors among young adults: a national population-based study.Frontiers in public health · 2025Article
- Perceived neighborhood safety, crime exposure, and chronic diseases among older Indians: The role of functional disabilities.PLOS global public health · 2025Article
- Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundMultimorbidity is linked to poor quality of life, and increased healthcare costs, and multimorbidity risk is potentially mitigated by a healthy lifestyle. This study evaluated the individual and joint contributions of an extensive set of lifestyle factors to the development of multimorbidity.
methodsA prospective study of 133,719 adults (age 45.2 ± 12.9, range 18-93 years) from the Dutch Lifelines cohort assessed the influence of lifestyle factors on multimorbidity, defined as having at least two of four major chronic diseases, using Cox regression models and population attributable fractions (PAFs). Lifestyle-related factors included diet quality, physical activity, TV watching, substance use (alcohol, smoking), sleep (duration, medication), stress (acute, chronic) and social connectedness (social contacts, marital status).
resultsOver a median follow-up of 3.4 years, 3687 (12.5%) of the 29,545 participants with a chronic disease at baseline developed multimorbidity, compared to 434 (0.4%) of the 104,174 without a chronic disease. Key lifestyle factors linked to multimorbidity included smoking, prolonged TV watching, and stress, with hazard ratios indicating a higher risk in both groups. Additionally, high alcohol consumption and inadequate sleep duration were found to increase multimorbidity risk specifically in those with a chronic disease. Lifestyle factors jointly accounted for 34.4% (PAF, 95%CI 28.8%-73.5%) (with baseline morbidity) and 55.6% (95%CI 17.2%-48.5%) (without) of multimorbidity cases, with smoking as the primary contributor.
conclusionsLifestyle factors, particularly smoking, alcohol consumption, TV watching, stress, and sleep, significantly contribute to the development of multimorbidity. The study underscores the importance of targeted prevention in public health and healthcare settings to manage and prevent multimorbidity.
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