Evidence map›Paper›PMID 39609295›Full record

ArticleClinical oral investigations2024

Combined catalytic strategies applied to in-office tooth bleaching: whitening efficacy, cytotoxicity, and gene expression of human dental pulp cells in a 3D culture model.

Rafael Antonio de Oliveira Ribeiro, Victória Peruchi, Igor Paulino Mendes Soares, Filipe Koon Wu Mon, Diana Gabriela Soares, Josimeri Hebling, Carlos Alberto de Souza Costa

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Rafael Antonio de Oliveira RibeiroDepartment of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Victória PeruchiDepartment of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Igor Paulino Mendes SoaresDepartment of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Filipe Koon Wu MonDepartment of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Diana Gabriela SoaresDepartment of Operative Dentistry, Endodontics and Dental Materials, School of Dentistry, University of São Paulo (USP), Bauru, Brazil.
Josimeri HeblingDepartment of Morphology, Genetics, Orthodontics and Pediatric Dentistry, School of Dentistry, São Paulo State University (UNESP), Araraquara, Brazil.
Carlos Alberto de Souza CostaDepartment of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Rua Humaitá, Araraquara, São Paulo, 1680, 14801-903, Brazil. cas.costa@unesp.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 302047/2019-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2021/01184-4Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/02780-5
6 · The paper itself

Abstract

objectivesTo evaluate the feasibility of using a 3D model with human dental pulp cells (HDPCs) to compare bleaching therapies and assess whether coating enamel with a nanofiber scaffold (NS) and polymeric catalyst primer (PCP), combined with violet LED (LEDv) irradiation, enhances bleaching efficacy (BE) and reduces cytotoxicity (CT). MATERIALS AND

methodsAfter using NS + PCP to cover enamel of enamel/dentin discs adapted to artificial pulp chambers containing 3D culture with HDPCs, a bleaching gel with 35%H

resultsBE showed no significant difference between PC and EXP (p > 0.05). EXP had lower oxidative stress, higher cell viability, reduced inflammatory marker expression, and increased mineralization marker expression compared to PC (p < 0.05).

conclusionThe 3D model using HDPCs effectively compared bleaching protocols. Coating enamel with NS + PCP and applying violet LED (LEDv) reduced bleaching time from 45 to 15 min while lowering cytotoxicity compared to conventional in-office treatments. CLINICAL RELEVANCE: This study shows that a 3D model with human dental pulp cells (HDPCs) effectively compares tooth bleaching protocols. The combination of a nanofiber scaffold with violet LED (LEDv) reduces bleaching time, as well as minimizes cytotoxicity and inflammation, offering a safer alternative to conventional treatments.

Indexed as

Cell Culture Techniques, Three DimensionalDental PulpHydrogen PeroxideNanofibersTooth BleachingTooth Bleaching AgentsCells, CulturedCell SurvivalDental EnamelFeasibility StudiesGene ExpressionHumansTissue ScaffoldsHydrogen PeroxideTooth Bleaching Agents3D cultureCatalysisDental pulpGene expressionTooth bleaching

Identifiers

PMID39609295

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.