ArticleEuropean radiology2025
Photon-counting detector CT provides superior subsolid nodule characterization compared to same-day energy-integrating detector CT.
Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Complications of minimally invasive treatments of benign thyroid nodules: preventive andmanaging strategies: A systematic review.La Radiologia medica · 2026Pooled it
- Diagnostic performance based on MRI for preoperative of vessels encapsulating tumor clusters in hepatocellular carcinoma: a systematic review and meta-analysis.La Radiologia medica · 2025Pooled it
- Photon-counting detector computed tomography in thoracic oncology: revolutionizing tumor imaging through precision and detail.Diagnostic and interventional radiology (Ankara, Turkey) · 2026Review
- Coronary artery calcium scoring: expanding the new standard by photon-counting detector CT-Part I: Impact of tube voltage, tube current, slice thickness, and quantum iterative reconstructions.European radiology · 2026Article
- Analysis of colorectal liver metastases in photon-counting detector CT - optimizing imaging through spectral reconstruction.Cancer imaging : the official publication of the International Cancer Imaging Society · 2026Article
- Photon-counting detector CT in oncology: a new era of cancer imaging.Insights into imaging · 2026Review
- Ultra-high spatial resolution at photon-counting computed tomography: technical insights and sustainable applications in cardiothoracic imaging.European radiology experimental · 2026Review
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Authors and funding
17 authors.
Funding
Abstract
purposeTo investigate the image quality and the performance of photon-counting detector (PCD) CT compared to conventional energy-integrating detector (EID) CT in identifying subsolid nodule (SSN) characteristics. MATERIALS AND
methodsParticipants with SSNs who underwent same-day EID CT and PCD CT between October 2023 and April 2024 were prospectively included. The 1.0 mm EID CT images and, subsequently, 1.0 mm, 0.4 mm, and 0.2 mm PCD CT images were reviewed to assess image noise and subjective image quality on a 5-point Likert scale. SSN characteristics, including lobulation, spiculation, pleural retraction, air cavities, intra-nodular vessel signs, internal vascular changes, and heterogeneous solid components, were evaluated. Additionally, a step-by-step observation and comparison method was used to determine the presence of any additional characteristics.
resultsForty-eight participants (mean age: 56 ± 11 years; 16 males) with 89 SSNs were included. PCD CT significantly reduced radiation dose when using matched scans (1.79 ± 0.39 vs 2.17 ± 0.57 mSv, p < 0.001). Compared to 1.0 mm EID CT, 1.0 mm PCD CT images exhibited significantly lower objective image noise and higher subjective image quality (all p < 0.001). Compared to EID CT, PCD CT demonstrated enhanced visualization of subtle characteristics, except for lobulation, with a 0.4 mm section thickness offering a favorable balance between ultra-high resolution and perceived image quality for radiologists.
conclusionPCD CT facilitated radiation dose reduction and outperformed conventional EID CT in terms of image quality and visualization of SSN characteristics. KEY POINTS: Question PCD CT, featuring ultra-high-resolution mode acquisition and a thinner reconstruction, has not been fully explored for characterizing SSNs. Findings Compared to EID CT, PCD CT was associated with lower objective image noise, higher subjective image quality, and superior SSN characterization. Clinical relevance PCD CT effectively reduced the radiation dose delivered to the patients and enabled more precise SSN characterization.
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Registered trials
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